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Open AccessArticle

Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension

Department of Nutrition and Health Sceinces, School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
Department of Food Science, College of Agriculture, Tunghai University, Taichung 407, Taiwan
Department of Anatomic Pathology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan
College of Nursing, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan
Department of Nutrition, I-Shou University, Kaohsiung 82445, Taiwan
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1521;
Received: 15 September 2018 / Revised: 1 October 2018 / Accepted: 11 October 2018 / Published: 17 October 2018
Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day Nω-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. During the experimental period, antroquinonol reduced the elevation of systolic and diastolic blood pressure. At the end of the study, we found that the antroquinonol groups had lower serum creatinine, renal endothelin-1, angiotensin II, and malondialdehyde levels and arteriole thickening. We found that the 40 mg/kg/day antroquinonol group had lower renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activities, greater nuclear factor erythroid-2, and heme oxygenase-1 expressions. Moreover, we also found that antroquinonol decreased proinflammatory cytokine concentrations in the kidney by modulating the nuclear factor-κB pathway. These results suggest that antroquinonol may ameliorate hypertension and improve renal function by reducing oxidative stress and inflammation in rats with endothelial dysfunction. View Full-Text
Keywords: antroquinonol; hypertension; nitric oxide; Nrf-2; inflammation antroquinonol; hypertension; nitric oxide; Nrf-2; inflammation
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MDPI and ACS Style

Chen, J.-R.; Ko, J.; Yeh, W.-J.; Huang, W.-C.; Yang, H.-Y. Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension. Nutrients 2018, 10, 1521.

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