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Nutrients 2018, 10(10), 1521; https://doi.org/10.3390/nu10101521

Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension

1
Department of Nutrition and Health Sceinces, School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
2
Department of Food Science, College of Agriculture, Tunghai University, Taichung 407, Taiwan
3
Department of Anatomic Pathology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan
4
College of Nursing, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan
5
Department of Nutrition, I-Shou University, Kaohsiung 82445, Taiwan
*
Author to whom correspondence should be addressed.
Received: 15 September 2018 / Revised: 1 October 2018 / Accepted: 11 October 2018 / Published: 17 October 2018
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Abstract

Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day Nω-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. During the experimental period, antroquinonol reduced the elevation of systolic and diastolic blood pressure. At the end of the study, we found that the antroquinonol groups had lower serum creatinine, renal endothelin-1, angiotensin II, and malondialdehyde levels and arteriole thickening. We found that the 40 mg/kg/day antroquinonol group had lower renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activities, greater nuclear factor erythroid-2, and heme oxygenase-1 expressions. Moreover, we also found that antroquinonol decreased proinflammatory cytokine concentrations in the kidney by modulating the nuclear factor-κB pathway. These results suggest that antroquinonol may ameliorate hypertension and improve renal function by reducing oxidative stress and inflammation in rats with endothelial dysfunction. View Full-Text
Keywords: antroquinonol; hypertension; nitric oxide; Nrf-2; inflammation antroquinonol; hypertension; nitric oxide; Nrf-2; inflammation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chen, J.-R.; Ko, J.; Yeh, W.-J.; Huang, W.-C.; Yang, H.-Y. Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension. Nutrients 2018, 10, 1521.

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