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Open AccessArticle

Sialic Acid and Sialylated Oligosaccharide Supplementation during Lactation Improves Learning and Memory in Rats

1
R&D Abbott Nutrition, 18004 Granada, Spain
2
Doctoral programme in Biomedicine, School of Health Sciences, University of Granada, 18071 Granada, Spain
3
Division of Neurosciences, Pablo de Olavide University, 41013 Seville, Spain
4
R&D Abbott Nutrition, Columbus, OH 43219, USA
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1519; https://doi.org/10.3390/nu10101519
Received: 3 September 2018 / Revised: 8 October 2018 / Accepted: 11 October 2018 / Published: 16 October 2018
Sialic acids (Sia) are postulated to improve cognitive abilities. This study evaluated Sia effects on rat behavior when administered in a free form as N-acetylneuraminic acid (Neu5Ac) or conjugated as 6′-sialyllactose (6′-SL). Rat milk contains Sia, which peaks at Postnatal Day 9 and drops to a minimum by Day 15. To bypass this Sia peak, a cohort of foster mothers was used to raise the experimental pups. A group of pups received a daily oral supplementation of Neu5Ac to mimic the amount naturally present in rat milk, and another group received the same molar amount of Sia as 6′-SL. The control group received water. After weaning, rats were submitted to behavioral evaluation. One year later, behavior was re-evaluated, and in vivo long-term potentiation (LTP) was performed. Brain samples were collected and analyzed at both ages. Adult rats who received Sia performed significantly better in the behavioral assessment and showed an enhanced LTP compared to controls. Within Sia groups, 6′-SL rats showed better scores in some cognitive outcomes compared to Neu5Ac rats. At weaning, an effect on polysialylated-neural cell adhesion molecule (PSA-NCAM) levels in the frontal cortex was only observed in 6′-SL fed rats. Providing Sia during lactation, especially as 6′-SL, improves memory and LTP in adult rats. View Full-Text
Keywords: milk oligosaccharides; infant formula; 6′-sialyllactose; cognitive development; sialic acid milk oligosaccharides; infant formula; 6′-sialyllactose; cognitive development; sialic acid
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Oliveros, E.; Vázquez, E.; Barranco, A.; Ramírez, M.; Gruart, A.; Delgado-García, J.M.; Buck, R.; Rueda, R.; Martín, M.J. Sialic Acid and Sialylated Oligosaccharide Supplementation during Lactation Improves Learning and Memory in Rats. Nutrients 2018, 10, 1519.

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