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Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model

by 1,†, 1,†, 2,3 and 1,4,*
1
College of Medicine, Gachon University, Incheon 21999, Korea
2
College of Pharmacy, Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Korea
3
Department of Pharmacognosy, College of Pharmacy, Government College University Faisalabad, Faisalabad 38000, Pakistan
4
Department of Health Science and Technology, GAIHST, Gachon University, Incheon 21936, Korea
*
Author to whom correspondence should be addressed.
The first two authors contributed equally to this article.
Nutrients 2018, 10(10), 1475; https://doi.org/10.3390/nu10101475
Received: 31 August 2018 / Revised: 2 October 2018 / Accepted: 6 October 2018 / Published: 10 October 2018
(This article belongs to the Special Issue Nutrition and Functional Abdominal Pain)
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder manifesting as unexplained abdominal pain and bowel habit changes. The pathogenesis of post-infectious IBS is associated with gut–brain axis dysfunction, including low-grade colonic inflammation and anxiety-related long-term brain changes. This study analyzed the efficacy of a standardized extract of Dolichos lablab L. extract (DL), a bean species, in an IBS mouse model resembling post-infectious, diarrhea-dominant IBS. Using a zymosan-induced animal IBS model, we found that oral administration of DL significantly attenuated zymosan-induced increases in colonic macroscopic scores and minimized weight loss without affecting food intake. In the DL-treated mice, the mast cell count and tumor necrosis factor-α level in the colon markedly decreased, similar to results in sulfasalazine-treated mice and in mice with lipopolysaccharide-stimulated bone marrow-derived mast cells. The number of visceral pain-related behaviors was much lower in the DL-treated mice. Anxiety-like behaviors significantly improved, comparable to that after treatment with amitriptyline. The c-Fos expression level in the prefrontal cortex was significantly reduced. Our data suggest that DL could be beneficial for treating IBS by acting on the gut and brain. View Full-Text
Keywords: irritable bowel syndrome; Dolichos lablab L.; zymosan-induced IBS; mouse model; gut–brain axis; colonic inflammation; pain; anxiety irritable bowel syndrome; Dolichos lablab L.; zymosan-induced IBS; mouse model; gut–brain axis; colonic inflammation; pain; anxiety
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MDPI and ACS Style

Chun, E.; Yoon, S.; Parveen, A.; Jin, M. Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model. Nutrients 2018, 10, 1475. https://doi.org/10.3390/nu10101475

AMA Style

Chun E, Yoon S, Parveen A, Jin M. Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model. Nutrients. 2018; 10(10):1475. https://doi.org/10.3390/nu10101475

Chicago/Turabian Style

Chun, Eunho; Yoon, Soojung; Parveen, Amna; Jin, Mirim. 2018. "Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model" Nutrients 10, no. 10: 1475. https://doi.org/10.3390/nu10101475

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