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Nutrients 2018, 10(10), 1475; https://doi.org/10.3390/nu10101475

Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model

1,†
,
1,†
,
2,3
and
1,4,*
1
College of Medicine, Gachon University, Incheon 21999, Korea
2
College of Pharmacy, Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Korea
3
Department of Pharmacognosy, College of Pharmacy, Government College University Faisalabad, Faisalabad 38000, Pakistan
4
Department of Health Science and Technology, GAIHST, Gachon University, Incheon 21936, Korea
The first two authors contributed equally to this article.
*
Author to whom correspondence should be addressed.
Received: 31 August 2018 / Revised: 2 October 2018 / Accepted: 6 October 2018 / Published: 10 October 2018
(This article belongs to the Special Issue Nutrition and Functional Abdominal Pain)
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Abstract

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder manifesting as unexplained abdominal pain and bowel habit changes. The pathogenesis of post-infectious IBS is associated with gut–brain axis dysfunction, including low-grade colonic inflammation and anxiety-related long-term brain changes. This study analyzed the efficacy of a standardized extract of Dolichos lablab L. extract (DL), a bean species, in an IBS mouse model resembling post-infectious, diarrhea-dominant IBS. Using a zymosan-induced animal IBS model, we found that oral administration of DL significantly attenuated zymosan-induced increases in colonic macroscopic scores and minimized weight loss without affecting food intake. In the DL-treated mice, the mast cell count and tumor necrosis factor-α level in the colon markedly decreased, similar to results in sulfasalazine-treated mice and in mice with lipopolysaccharide-stimulated bone marrow-derived mast cells. The number of visceral pain-related behaviors was much lower in the DL-treated mice. Anxiety-like behaviors significantly improved, comparable to that after treatment with amitriptyline. The c-Fos expression level in the prefrontal cortex was significantly reduced. Our data suggest that DL could be beneficial for treating IBS by acting on the gut and brain. View Full-Text
Keywords: irritable bowel syndrome; Dolichos lablab L.; zymosan-induced IBS; mouse model; gut–brain axis; colonic inflammation; pain; anxiety irritable bowel syndrome; Dolichos lablab L.; zymosan-induced IBS; mouse model; gut–brain axis; colonic inflammation; pain; anxiety
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chun, E.; Yoon, S.; Parveen, A.; Jin, M. Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model. Nutrients 2018, 10, 1475.

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