Next Article in Journal
Association of Coffee Consumption with Hearing and Tinnitus Based on a National Population-Based Survey
Previous Article in Journal
Addictive Eating and Its Relation to Physical Activity and Sleep Behavior
Article Menu

Export Article

Open AccessArticle
Nutrients 2018, 10(10), 1430; https://doi.org/10.3390/nu10101430

Welsh Onion Root (Allium fistulosum) Restores Ovarian Functions from Letrozole Induced-Polycystic Ovary Syndrome

1
College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea
2
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 4 September 2018 / Revised: 27 September 2018 / Accepted: 1 October 2018 / Published: 4 October 2018
Full-Text   |   PDF [3118 KB, uploaded 4 October 2018]   |  

Abstract

Polycystic ovarian syndrome (PCOS) is an endocrine, metabolic, and systemic disease. It is mainly characterized by hyperandrogenism, oligomenorrhea, and high levels of luteinizing hormone (LH). There is no obvious therapy for PCOS, so patients have received symptomatic therapy. Welsh onion (Allium fistulosum) is well-known in Asian countries for its usage in food ingredients and traditional medicines. It is also studied for its many effects. These include activation of immune responses, antihypertensive effects, and antioxidant effects. Using letrozole-induced PCOS rats, we focused on herbal therapy using extract of Allium fistulosum (AF; A. fistulosum) roots to improve ovarian functions. As a nonsteroidal aromatase inhibitor, letrozole blocks conversion of testosterone to estrogen and subsequently induces PCOS phenomenon. We divided six-week-old female rats into four groups, including control, letrozole, letrozole + AF extract, and temporary letrozole groups. In our study, treatment with AF extract shows a low plasma LH/FSH ratio, and reveals high estrogen levels, ovarian morphology, folliculogenesis-related genes, and aromatase expression under PCOS mimic conditions. We concluded that AF extract administration influenced aromatase production, enhanced the estrogen steroid synthesis, and consequently restored the estrogenic feedback mechanism on the pituitary-ovary system. View Full-Text
Keywords: Ovarian failure; Polycystic ovary syndrome; Allium fistulosum; LH; FSH Ovarian failure; Polycystic ovary syndrome; Allium fistulosum; LH; FSH
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Lee, Y.H.; Yang, H.; Lee, S.R.; Kwon, S.W.; Hong, E.-J.; Lee, H.W. Welsh Onion Root (Allium fistulosum) Restores Ovarian Functions from Letrozole Induced-Polycystic Ovary Syndrome. Nutrients 2018, 10, 1430.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top