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Nutrients 2018, 10(10), 1430;

Welsh Onion Root (Allium fistulosum) Restores Ovarian Functions from Letrozole Induced-Polycystic Ovary Syndrome

College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 4 September 2018 / Revised: 27 September 2018 / Accepted: 1 October 2018 / Published: 4 October 2018
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Polycystic ovarian syndrome (PCOS) is an endocrine, metabolic, and systemic disease. It is mainly characterized by hyperandrogenism, oligomenorrhea, and high levels of luteinizing hormone (LH). There is no obvious therapy for PCOS, so patients have received symptomatic therapy. Welsh onion (Allium fistulosum) is well-known in Asian countries for its usage in food ingredients and traditional medicines. It is also studied for its many effects. These include activation of immune responses, antihypertensive effects, and antioxidant effects. Using letrozole-induced PCOS rats, we focused on herbal therapy using extract of Allium fistulosum (AF; A. fistulosum) roots to improve ovarian functions. As a nonsteroidal aromatase inhibitor, letrozole blocks conversion of testosterone to estrogen and subsequently induces PCOS phenomenon. We divided six-week-old female rats into four groups, including control, letrozole, letrozole + AF extract, and temporary letrozole groups. In our study, treatment with AF extract shows a low plasma LH/FSH ratio, and reveals high estrogen levels, ovarian morphology, folliculogenesis-related genes, and aromatase expression under PCOS mimic conditions. We concluded that AF extract administration influenced aromatase production, enhanced the estrogen steroid synthesis, and consequently restored the estrogenic feedback mechanism on the pituitary-ovary system. View Full-Text
Keywords: Ovarian failure; Polycystic ovary syndrome; Allium fistulosum; LH; FSH Ovarian failure; Polycystic ovary syndrome; Allium fistulosum; LH; FSH

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Lee, Y.H.; Yang, H.; Lee, S.R.; Kwon, S.W.; Hong, E.-J.; Lee, H.W. Welsh Onion Root (Allium fistulosum) Restores Ovarian Functions from Letrozole Induced-Polycystic Ovary Syndrome. Nutrients 2018, 10, 1430.

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