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Open AccessArticle

Achacha (Garcinia humilis) Rind Improves Cardiovascular Function in Rats with Diet-Induced Metabolic Syndrome

1
Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia
2
School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia
3
Analytical Research Laboratory, Southern Cross Plant Science, Southern Cross University, Lismore, NSW 2480, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1425; https://doi.org/10.3390/nu10101425
Received: 15 August 2018 / Revised: 14 September 2018 / Accepted: 26 September 2018 / Published: 4 October 2018
(This article belongs to the Special Issue Nutrients for Cardiometabolic Health and Brain Function)
Garcinia humilis is a fruit known as achachairú. It is native to South American countries such as Bolivia, Peru, and Brazil, but it is also cultivated as achacha in northern Australia. The aim of this study was to determine the phytochemicals in achacha rind and pulp and to investigate these components as potential treatments for the symptoms of metabolic syndrome. Both rind and pulp contain procyanidins and citric acid rather than hydroxycitric acid. Male Wistar rats (8–9 weeks old) were fed with either high-carbohydrate, high-fat, or corn starch diets for 16 weeks. Intervention groups were fed with either diet supplemented with 1.5% G. humilis rind powder or 2.0% G. humilis pulp for the last 8 weeks of the protocol. Rats fed a high-carbohydrate, high-fat diet exhibited hypertension, dyslipidemia, central obesity, impaired glucose tolerance, and non-alcoholic fatty liver disease. G. humilis rind decreased systolic blood pressure, diastolic stiffness, left ventricular inflammatory cell infiltration, and collagen deposition in high-carbohydrate, high-fat diet-fed rats. However, there was no change in glucose tolerance, body weight, or body composition. Therefore, G. humilis rind, usually a food by-product, but not the edible pulp, showed potential cardioprotection with minimal metabolic changes in a rat model of diet-induced metabolic syndrome. View Full-Text
Keywords: metabolic syndrome; obesity; inflammation; Garcinia humilis; blood pressure; procyanidin; flavonoids metabolic syndrome; obesity; inflammation; Garcinia humilis; blood pressure; procyanidin; flavonoids
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MDPI and ACS Style

John, O.D.; Wanyonyi, S.; Mouatt, P.; Panchal, S.K.; Brown, L. Achacha (Garcinia humilis) Rind Improves Cardiovascular Function in Rats with Diet-Induced Metabolic Syndrome. Nutrients 2018, 10, 1425. https://doi.org/10.3390/nu10101425

AMA Style

John OD, Wanyonyi S, Mouatt P, Panchal SK, Brown L. Achacha (Garcinia humilis) Rind Improves Cardiovascular Function in Rats with Diet-Induced Metabolic Syndrome. Nutrients. 2018; 10(10):1425. https://doi.org/10.3390/nu10101425

Chicago/Turabian Style

John, Oliver D.; Wanyonyi, Stephen; Mouatt, Peter; Panchal, Sunil K.; Brown, Lindsay. 2018. "Achacha (Garcinia humilis) Rind Improves Cardiovascular Function in Rats with Diet-Induced Metabolic Syndrome" Nutrients 10, no. 10: 1425. https://doi.org/10.3390/nu10101425

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