Next Article in Journal
What is the Validity of Questionnaires Assessing Fruit and Vegetable Consumption in Children when Compared with Blood Biomarkers? A Meta-Analysis
Previous Article in Journal
A Combined Dietary and Cognitive Intervention in 3–5-Year-Old Children in Indonesia: A Randomized Controlled Trial
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Nutrients 2018, 10(10), 1395; https://doi.org/10.3390/nu10101395

The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis

1
Department of the College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, China
2
Department of the medical college of Qingdao University, Qingdao 266021, China
*
Author to whom correspondence should be addressed.
Received: 7 July 2018 / Revised: 25 August 2018 / Accepted: 10 September 2018 / Published: 1 October 2018
Full-Text   |   PDF [1500 KB, uploaded 10 October 2018]   |  

Abstract

Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included. By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72). Subgroup analysis showed that VDD also was associated with poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05), short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and sleepiness (OR: 1.36, 95% CI: 1.12, 1.65). Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep. This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association. View Full-Text
Keywords: vitamin D; serum 25(OH)D; sleep; sleep quality; sleep duration; sleep disorders vitamin D; serum 25(OH)D; sleep; sleep quality; sleep duration; sleep disorders
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Gao, Q.; Kou, T.; Zhuang, B.; Ren, Y.; Dong, X.; Wang, Q. The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis. Nutrients 2018, 10, 1395.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top