Fulminating Septic Shock from Clostridium Perfringens in an Early Breast Cancer Patient with Severe Myalgia after Docetaxel Treatment

Alessandro Marco Minisini; Jessica Menis; Alessandro Follador; Claudio Avellini; Gianpiero Fasola

doi:10.4081/cp.2011.e33

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Case Report

12 May 2011

Fulminating Septic Shock from Clostridium Perfringens in an Early Breast Cancer Patient with Severe Myalgia after Docetaxel Treatment

and

Department of Oncology, University and General Hospital of Udine, 33100 Udine, Italy

Department of Pathology, University and General Hospital of Udine, 33100 Udine, Italy

Author to whom correspondence should be addressed.

Clin. Pract.2011, 1(2), e33;https://doi.org/10.4081/cp.2011.e33

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Abstract

Anaerobic bacteraemia could be a lifethreatening condition in neutropenic patients receiving chemotherapy. Taxane therapy is associated with necrotising inflammation of the caecum (named also typhlitis) that could be a potential source for bacteraemia. We report the case of a sudden onset of septic shock by Clostridium perfringens in a young patient treated with docetaxel as adjuvant chemotherapy for early breast cancer. A minireview of the literature has been performed.

Keywords:

breast cancer; docetaxel; septic shock; neutropenia

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