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Microbiology Research
Volume 6
Issue 1
10.4081/mr.2015.5800
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Article

Bioactive Isochromenone Isolated from Aspergillus fumigatus, Endophytic Fungus from Bacopa monnieri

by
Jay Prakash Thakur
,
Rumana Haider
,
Dhananjay Kumar Singh
,
Balagani Sathish Kumar
,
Prema G. Vasudev
,
Suaib Luqman
,
Alok Kalra
,
Dharmendra Saikia
and
Arvind S. Negi
*
CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India
*
Author to whom correspondence should be addressed.
Microbiol. Res. 2015, 6(1), 5800; https://doi.org/10.4081/mr.2015.5800
Submission received: 7 January 2015 / Revised: 19 October 2015 / Accepted: 19 October 2015 / Published: 30 December 2015

Abstract

Fungal endophytes are a significant reservoir of novel bioactive secondary metabolites. Present communication describes isolation and structure determination of isochromenone, from endophytic microorganism Aspergillus fumigatus hosted in Bacopa monnieri plant. Further, its biological evaluation revealed it as antioxidant and antitubercular. The methanol extract of A. fumigatus inhibits the growth of the virulent strain of Mycobacterium tuberculosis H37RV with minimum inhibitory concentration 500 μg/mL. This is the first report of isolation of isochromenone from A. fumigatus.
Keywords: Bacopa monnieri; Aspergillus fumigatus; endophyte; isochromenone; antioxidant Bacopa monnieri; Aspergillus fumigatus; endophyte; isochromenone; antioxidant

Share and Cite

MDPI and ACS Style

Thakur, J.P.; Haider, R.; Singh, D.K.; Kumar, B.S.; Vasudev, P.G.; Luqman, S.; Kalra, A.; Saikia, D.; Negi, A.S. Bioactive Isochromenone Isolated from Aspergillus fumigatus, Endophytic Fungus from Bacopa monnieri. Microbiol. Res. 2015, 6, 5800. https://doi.org/10.4081/mr.2015.5800

AMA Style

Thakur JP, Haider R, Singh DK, Kumar BS, Vasudev PG, Luqman S, Kalra A, Saikia D, Negi AS. Bioactive Isochromenone Isolated from Aspergillus fumigatus, Endophytic Fungus from Bacopa monnieri. Microbiology Research. 2015; 6(1):5800. https://doi.org/10.4081/mr.2015.5800

Chicago/Turabian Style

Thakur, Jay Prakash, Rumana Haider, Dhananjay Kumar Singh, Balagani Sathish Kumar, Prema G. Vasudev, Suaib Luqman, Alok Kalra, Dharmendra Saikia, and Arvind S. Negi. 2015. "Bioactive Isochromenone Isolated from Aspergillus fumigatus, Endophytic Fungus from Bacopa monnieri" Microbiology Research 6, no. 1: 5800. https://doi.org/10.4081/mr.2015.5800

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