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Microbiology Research
Volume 6
Issue 1
10.4081/mr.2015.6158
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Article

The Novel Effect of cis-2-Decenoic Acid on Biofilm Producing Pseudomonas aeruginosa

by
Vahid Soheili
1,
Neda Khedmatgozar Oghaz
1,
Zahra Sabeti Noughabi
2 and
Bibi Sedigheh Fazly Bazzaz
3,*
1
Department of Drug and Food Control, Iran
2
School of Pharmacy, Iran
3
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
*
Author to whom correspondence should be addressed.
Microbiol. Res. 2015, 6(1), 6158; https://doi.org/10.4081/mr.2015.6158
Submission received: 24 August 2015 / Revised: 9 November 2015 / Accepted: 24 November 2015 / Published: 12 February 2016

Abstract

Microbial biofilms are a main cause of many chronic infections and mortalities, such as dental caries, cystic fibrosis, osteoradionecrosis, urinary tract infections and native valve endocarditis. These polymeric matrices are sessile communities with different rules from those forms via known planktonic bacteria. One of the important biofilm-producing human pathogens is Pseudomonas aeruginosa, which causes death in the majority of people who suffer from cystic fibrosis, AIDS, burns and neutropenic cancer. To find a method for controlling the growth and resistance of P. aeruginosa biofilm, this study investigated the dispersion induction of this microorganism with a diffusible signal factor (DSF), cis-2-decenoic acid (CDA), in combination with Tobramycin as a useful antibiotic. Our findings confirmed that although CDA did not act as a dispersion inducer in this experiment, it did show an antimicrobial effect and decreased the MIC of Tobramycin. These results suggested that research on the probable new effects of DSF molecules will result in advances in the control of biofilm infections.
Keywords: Biofilms; cis-2-decenoic acid; DSF; Pseudomonas aeruginosa; Tobramycin Biofilms; cis-2-decenoic acid; DSF; Pseudomonas aeruginosa; Tobramycin

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MDPI and ACS Style

Soheili, V.; Khedmatgozar Oghaz, N.; Sabeti Noughabi, Z.; Fazly Bazzaz, B.S. The Novel Effect of cis-2-Decenoic Acid on Biofilm Producing Pseudomonas aeruginosa. Microbiol. Res. 2015, 6, 6158. https://doi.org/10.4081/mr.2015.6158

AMA Style

Soheili V, Khedmatgozar Oghaz N, Sabeti Noughabi Z, Fazly Bazzaz BS. The Novel Effect of cis-2-Decenoic Acid on Biofilm Producing Pseudomonas aeruginosa. Microbiology Research. 2015; 6(1):6158. https://doi.org/10.4081/mr.2015.6158

Chicago/Turabian Style

Soheili, Vahid, Neda Khedmatgozar Oghaz, Zahra Sabeti Noughabi, and Bibi Sedigheh Fazly Bazzaz. 2015. "The Novel Effect of cis-2-Decenoic Acid on Biofilm Producing Pseudomonas aeruginosa" Microbiology Research 6, no. 1: 6158. https://doi.org/10.4081/mr.2015.6158

APA Style

Soheili, V., Khedmatgozar Oghaz, N., Sabeti Noughabi, Z., & Fazly Bazzaz, B. S. (2015). The Novel Effect of cis-2-Decenoic Acid on Biofilm Producing Pseudomonas aeruginosa. Microbiology Research, 6(1), 6158. https://doi.org/10.4081/mr.2015.6158

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