Safety and Efficacy of Low-Dose Eptifibatide for Tandem Occlusions in Acute Ischemic Stroke
Abstract
1. Introduction
2. Materials and Methods
Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patients Receiving Eptifibatide (n = 115) | Patients Not Receiving Eptifibatide (n = 33) | p Value (Fisher Exact Test) | |
---|---|---|---|
Age (years), mean (SD) | 65.0 (12.7) | 63.5 (14.1) | NS |
Males/females—n (%) | 86/29 (75/25) | 28/5 (85/15) | NS |
Medical history | |||
hypertension—n (%) | 67 (58) | 18 (55) | NS |
diabetes mellitus—n (%) | 42 (37) | 6 (18) | NS |
coronary disease—n (%) | 30 (26) | 6 (18) | NS |
history of myocardial infarction—n (%) | 19 (17) | 5 (15) | NS |
NIHSS at admission—mean (SD) | 14 (5.3) | 16 (4.7) | NS |
ASPECT at admission—mean (SD) | 8 (1.5) | 7 (1.4) | NS |
Extracranial carotid lesion | |||
Stenosis ≥ 80%—n (%) | 28 (24) | 9 (27) | NS |
Occlusion—n (%) | 87 (76) | 24 (73) | NS |
Intracranial occlusion location | |||
Middle cerebral artery or anterior cerebral artery—n (%) | 78 (68) | 25 (76) | NS |
Intracranial part of ICA—n (%) | 37 (32) | 8 (24) | NS |
Intracranial thrombectomy technique | |||
stent retriever—n (%) | 33 (29) | 13 (39) | NS |
aspiration alone—n (%) | 82 (71) | 20 (61) | NS |
Extracranial carotid procedure | |||
Angioplasty alone | 4 | 33 | |
Stenting | 111 | 0 |
Patients Receiving Eptifibatide (n = 115) | Patients Not Receiving Eptifibatide (n = 33) | Statistical Significance | |
---|---|---|---|
Stent and/or ICA thrombosis | 6 (5.2%) | 5 (15.2%) | NS |
Intracranial bleeding | 11 (9.5%) | 5 (15.2%) | NS |
Intracranial bleeding or thrombosis | 16 (13.9%) | 9 (27.3%) | NS |
30-day mortality of any cause | 9 (7.8%) | 3 (9.1%) | NS |
Mortality due to stroke | 4 (3.5%) | 2 (6.1%) | NS |
Median duration of hospital stay duration (days) * | 9 (3–38) | 10 (4–57) | NS |
Median score of the National Institutes of Health Stroke Scale at baseline | 15 (2–23) | 16 (5–24) | NS |
Median score of the National Institutes of Health Stroke Scale at 30-day follow-up * | 3 (0–36) | 7 (0–21) | NS |
Patients Receiving Eptifibatide (n = 115) | Patients Not Receiving Eptifibatide (n = 33) | |
---|---|---|
Patients without neurologic symptoms (NIHSS score: 0) | 26 (22.6%) | 3 (9.1%) |
Patients with mild stroke symptoms (NIHSS score: 1–4) | 41 (35.7%) | 9 (27.3%) |
Patients with moderate stroke symptoms (NIHSS score: 5–14) | 31 (27.0%) | 15 (45.5%) |
Patients with severe stroke symptoms (NIHSS score: 15–24) | 7 (6.1%) | 3 (9.1%) |
Patients with very severe stroke symptoms (NIHSS score: ≥25) | 1 (0.9%) | 0 |
Death before 30-day follow-up | 9 (7.8%) | 3 (9.1%) |
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Latacz, P.; Popiela, T.; Brzegowy, P.; Lasocha, B.; Kwiecień, K.; Simka, M. Safety and Efficacy of Low-Dose Eptifibatide for Tandem Occlusions in Acute Ischemic Stroke. Neurol. Int. 2024, 16, 253-262. https://doi.org/10.3390/neurolint16010017
Latacz P, Popiela T, Brzegowy P, Lasocha B, Kwiecień K, Simka M. Safety and Efficacy of Low-Dose Eptifibatide for Tandem Occlusions in Acute Ischemic Stroke. Neurology International. 2024; 16(1):253-262. https://doi.org/10.3390/neurolint16010017
Chicago/Turabian StyleLatacz, Paweł, Tadeusz Popiela, Paweł Brzegowy, Bartłomiej Lasocha, Krzysztof Kwiecień, and Marian Simka. 2024. "Safety and Efficacy of Low-Dose Eptifibatide for Tandem Occlusions in Acute Ischemic Stroke" Neurology International 16, no. 1: 253-262. https://doi.org/10.3390/neurolint16010017
APA StyleLatacz, P., Popiela, T., Brzegowy, P., Lasocha, B., Kwiecień, K., & Simka, M. (2024). Safety and Efficacy of Low-Dose Eptifibatide for Tandem Occlusions in Acute Ischemic Stroke. Neurology International, 16(1), 253-262. https://doi.org/10.3390/neurolint16010017