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Acute and Post-Acute Neurological Complications of COVID-19

by 1,2, 1,2, 1,2,3,4,5 and 1,2,3,5,*
1
Insight Research Institute, Flint, MI 48507, USA
2
Center for Cognition and Neuroethics, University of Michigan-Flint, Flint, MI 48502, USA
3
Insight Research Center, Insight Institute of Neurosurgery & Neuroscience, Flint, MI 48507, USA
4
Department of Medicine, Michigan State University, East Lansing, MI 48824, USA
5
Insight Surgical Hospital, Warren, MI 48091, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Cristoforo Comi
Neurol. Int. 2021, 13(1), 102-119; https://doi.org/10.3390/neurolint13010010
Received: 26 January 2021 / Revised: 1 March 2021 / Accepted: 5 March 2021 / Published: 9 March 2021
Coronavirus disease 2019 (COVID-19) is an emerging global health emergency caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The global outbreak of SARS-CoV-2 infection has been declared a global pandemic by the World Health Organization (WHO). The clinical presentation of SARS-CoV-2 infection depends on the severity of the disease and may range from an asymptomatic infection to a severe and lethal illness. Fever, cough, and shortness of breath are among the most common symptoms associated with SARS-CoV-2 infection. Accumulating evidence indicates that COVID-19 patients commonly develop neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. In this comprehensive literature review, we have summarized the most common neurological complications and reported neurological case studies associated with COVID-19, and neurological side effects associated with COVID-19 treatments. Additionally, the post-acute COVID-19 syndrome and long-term neurological complications were discussed. We also explained the proposed mechanisms that are involved in the pathogenesis of these neurological complications. View Full-Text
Keywords: SARS-CoV-2; COVID-19; neurological complications; cerebrovascular complications; encephalopathy; demyelinating disorders; nervous system invasion; molecular mimicry; COVID-19 treatments; post-acute COVID-19 syndrome SARS-CoV-2; COVID-19; neurological complications; cerebrovascular complications; encephalopathy; demyelinating disorders; nervous system invasion; molecular mimicry; COVID-19 treatments; post-acute COVID-19 syndrome
MDPI and ACS Style

Al-Ramadan, A.; Rabab’h, O.; Shah, J.; Gharaibeh, A. Acute and Post-Acute Neurological Complications of COVID-19. Neurol. Int. 2021, 13, 102-119. https://doi.org/10.3390/neurolint13010010

AMA Style

Al-Ramadan A, Rabab’h O, Shah J, Gharaibeh A. Acute and Post-Acute Neurological Complications of COVID-19. Neurology International. 2021; 13(1):102-119. https://doi.org/10.3390/neurolint13010010

Chicago/Turabian Style

Al-Ramadan, Ali; Rabab’h, Omar; Shah, Jawad; Gharaibeh, Abeer. 2021. "Acute and Post-Acute Neurological Complications of COVID-19" Neurol. Int. 13, no. 1: 102-119. https://doi.org/10.3390/neurolint13010010

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