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Neurology International
Volume 10
Issue 1
10.4081/ni.2018.7473
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Review

Cognitive Impairment in Neuromuscular Diseases: A Systematic Review

by
Marco Orsini
1,2,
Ana Carolina Andorinho de F. Ferreira
3,
Anna Carolina Damm de Assis
3,4,
Thais Magalhães
3,
Silmar Teixeira
2,
Victor Hugo Bastos
2,
Victor Marinho
2,*,
Thomaz Oliveira
2,
Rossano Fiorelli
1,
Acary Bulle Oliveira
4 and
Marcos R. G. de Freitas
5
1
Master's Program in Health Applied Sciences, Severino Sombra University, Vasssouras, Rio de Janeiro, Brazil
2
Brain Mapping and Plasticity Laboratory, Federal University of Piauí, Parnaíba, Brazil
3
Department of Neurology, Federal Fluminense University, Rio de Janeiro, Brazil
4
Department of Neurology, Federal University of São Paulo, Brazil
5
Department of Neurology, Federal University of Rio de Janeiro, Brazil
*
Author to whom correspondence should be addressed.
Neurol. Int. 2018, 10(1), 7473; https://doi.org/10.4081/ni.2018.7473
Submission received: 31 October 2017 / Revised: 4 December 2017 / Accepted: 12 December 2017 / Published: 4 July 2018

Abstract

Neuromuscular diseases are multifactorial pathologies characterized by extensive muscle fiber damage that leads to the activation of satellite cells and to the exhaustion of their pool, with consequent impairment of neurobiological aspects, such as cognition and motor control. To review the knowledge and obtain a broad view of the cognitive impairment on Neuromuscular Diseases. Cognitive impairment in neuromuscular disease was explored; a literature search up to October 2017 was conducted, including experimental studies, case reports and reviews written in English. Keywords included Cognitive Impairment, Neuromuscular Diseases, Motor Neuron Diseases, Dystrophinopathies and Mitochondrial Disorders. Several cognitive evaluation scales, neuroimaging scans, genetic analysis and laboratory applications in neuromuscular diseases, especially when it comes to the Motor Neuron Diseases, Dystrophinopathies and Mitochondrial Disorders. In addition, organisms model using rats in the genetic analysis and laboratory applications to verify the cognitive and neuromuscular impacts. Several studies indicate that congenital molecular alterations in neuromuscular diseases promote cognitive dysfunctions. Understanding these mechanisms may in the future guide the proper management of the patient, evaluation, establishment of prognosis, choice of treatment and development of innovative interventions such as gene therapy.
Keywords: Cognitive Impairment; Neuromuscular Diseases; Motor Neuron Diseases; Dystrophinopathies; Mitochondrial Disorders Cognitive Impairment; Neuromuscular Diseases; Motor Neuron Diseases; Dystrophinopathies; Mitochondrial Disorders

Share and Cite

MDPI and ACS Style

Orsini, M.; Andorinho de F. Ferreira, A.C.; Damm de Assis, A.C.; Magalhães, T.; Teixeira, S.; Bastos, V.H.; Marinho, V.; Oliveira, T.; Fiorelli, R.; Oliveira, A.B.; et al. Cognitive Impairment in Neuromuscular Diseases: A Systematic Review. Neurol. Int. 2018, 10, 7473. https://doi.org/10.4081/ni.2018.7473

AMA Style

Orsini M, Andorinho de F. Ferreira AC, Damm de Assis AC, Magalhães T, Teixeira S, Bastos VH, Marinho V, Oliveira T, Fiorelli R, Oliveira AB, et al. Cognitive Impairment in Neuromuscular Diseases: A Systematic Review. Neurology International. 2018; 10(1):7473. https://doi.org/10.4081/ni.2018.7473

Chicago/Turabian Style

Orsini, Marco, Ana Carolina Andorinho de F. Ferreira, Anna Carolina Damm de Assis, Thais Magalhães, Silmar Teixeira, Victor Hugo Bastos, Victor Marinho, Thomaz Oliveira, Rossano Fiorelli, Acary Bulle Oliveira, and et al. 2018. "Cognitive Impairment in Neuromuscular Diseases: A Systematic Review" Neurology International 10, no. 1: 7473. https://doi.org/10.4081/ni.2018.7473

APA Style

Orsini, M., Andorinho de F. Ferreira, A. C., Damm de Assis, A. C., Magalhães, T., Teixeira, S., Bastos, V. H., Marinho, V., Oliveira, T., Fiorelli, R., Oliveira, A. B., & de Freitas, M. R. G. (2018). Cognitive Impairment in Neuromuscular Diseases: A Systematic Review. Neurology International, 10(1), 7473. https://doi.org/10.4081/ni.2018.7473

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