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Neurology International
Volume 10
Issue 1
10.4081/ni.2018.7385
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Efficacy of Physical Therapy Associated with Botulinum Toxin Type A on Functional Performance in Post-Stroke Spasticity: A Randomized, Double-Blinded, Placebo-Controlled Trial

by
Antonio Prazeres
,
Marília Lira
,
Paula Aguiar
,
Larissa Monteiro
,
Ítalo Vilasbôas
and
Ailton Melo
*
Division of Neurology and Epidemiology, Federal University of Bahia, Salvador-Bahia, Brazil
*
Author to whom correspondence should be addressed.
Neurol. Int. 2018, 10(1), 7385; https://doi.org/10.4081/ni.2018.7385
Submission received: 27 August 2017 / Revised: 8 December 2017 / Accepted: 22 January 2018 / Published: 4 July 2018

Abstract

The aim was to investigate if botulinum toxin type A (BTx-A) associated with physical therapy is superior to physical therapy alone in post stroke spasticity. A randomized, double-blinded controlled trial was performed in a rehabilitation unit on Northeastern, Brazil. Patients with post stroke spasticity were enrolled either to BTx-A injections and a pre-defined program of physical therapy or saline injections plus physical therapy. Primary endpoint was functional performance evaluated through time up and go test, six minutes walking test and Fugl-Meyer scale for upper limb. Secondary endpoint was spasticity improvement. Confidence interval was considered at 95%. Although there was a significant decrease in upper limbs flexor tonus (P<0.05) in the BTx-A group, there was no difference regarding functional performance after 9 months of treatment. When analyzing gait speed and performance, both groups showed a significant improvement in the third month of treatment, however it was not sustained over time. Although BTx-A shows superiority to improve muscle tone, physical therapy is the cornerstone to improve function in the upper limbs of post stroke patients.
Keywords: Botulinum toxin; Physical therapy; Stroke; Spasticity; Clinical trial Botulinum toxin; Physical therapy; Stroke; Spasticity; Clinical trial

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MDPI and ACS Style

Prazeres, A.; Lira, M.; Aguiar, P.; Monteiro, L.; Vilasbôas, Í.; Melo, A. Efficacy of Physical Therapy Associated with Botulinum Toxin Type A on Functional Performance in Post-Stroke Spasticity: A Randomized, Double-Blinded, Placebo-Controlled Trial. Neurol. Int. 2018, 10, 7385. https://doi.org/10.4081/ni.2018.7385

AMA Style

Prazeres A, Lira M, Aguiar P, Monteiro L, Vilasbôas Í, Melo A. Efficacy of Physical Therapy Associated with Botulinum Toxin Type A on Functional Performance in Post-Stroke Spasticity: A Randomized, Double-Blinded, Placebo-Controlled Trial. Neurology International. 2018; 10(1):7385. https://doi.org/10.4081/ni.2018.7385

Chicago/Turabian Style

Prazeres, Antonio, Marília Lira, Paula Aguiar, Larissa Monteiro, Ítalo Vilasbôas, and Ailton Melo. 2018. "Efficacy of Physical Therapy Associated with Botulinum Toxin Type A on Functional Performance in Post-Stroke Spasticity: A Randomized, Double-Blinded, Placebo-Controlled Trial" Neurology International 10, no. 1: 7385. https://doi.org/10.4081/ni.2018.7385

APA Style

Prazeres, A., Lira, M., Aguiar, P., Monteiro, L., Vilasbôas, Í., & Melo, A. (2018). Efficacy of Physical Therapy Associated with Botulinum Toxin Type A on Functional Performance in Post-Stroke Spasticity: A Randomized, Double-Blinded, Placebo-Controlled Trial. Neurology International, 10(1), 7385. https://doi.org/10.4081/ni.2018.7385

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