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Pharmaceutics
Volume 15
Issue 3
10.3390/pharmaceutics15030809
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Article

Hybrid Materials with Antimicrobial Properties Based on Hyperbranched Polyaminopropylalkoxysiloxanes Embedded with Ag Nanoparticles

by
Alexander Vasil’kov
1,*,
Dmitry Migulin
2,
Alexander Naumkin
1,
Ilya Volkov
1,
Ivan Butenko
1,3,
Alexandre Golub
1,
Vera Sadykova
3 and
Aziz Muzafarov
1,2
1
A. N. Nesmeyanov Institute of Organoelement Compounds, RAS, 119991 Moscow, Russia
2
Enikolopov Institute of Synthetic Polymeric Materials, RAS, 117393 Moscow, Russia
3
G. F. Gause Institute of New Antibiotics, 119021 Moscow, Russia
*
Author to whom correspondence should be addressed.
Pharmaceutics 2023, 15(3), 809; https://doi.org/10.3390/pharmaceutics15030809
Submission received: 18 February 2023 / Accepted: 24 February 2023 / Published: 2 March 2023
(This article belongs to the Special Issue Pharmaceutical Formulations with Antimicrobial Properties, 2nd Edition)
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Abstract

New hybrid materials based on Ag nanoparticles stabilized by a polyaminopropylalkoxysiloxane hyperbranched polymer matrix were prepared. The Ag nanoparticles were synthesized in 2-propanol by metal vapor synthesis (MVS) and incorporated into the polymer matrix using metal-containing organosol. MVS is based on the interaction of extremely reactive atomic metals formed by evaporation in high vacuum (10−4–10−5 Torr) with organic substances during their co-condensation on the cooled walls of a reaction vessel. Polyaminopropylsiloxanes with hyperbranched molecular architectures were obtained in the process of heterofunctional polycondensation of the corresponding AB2-type monosodiumoxoorganodialkoxysilanes derived from the commercially available aminopropyltrialkoxysilanes. The nanocomposites were characterized using transmission (TEM) and scanning (SEM) electron microscopy, X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (PXRD) and Fourier-transform infrared spectroscopy (FTIR). TEM images show that Ag nanoparticles stabilized in the polymer matrix have an average size of 5.3 nm. In the Ag-containing composite, the metal nanoparticles have a “core-shell” structure, in which the “core” and “shell” represent the M0 and Mδ+ states, respectively. Nanocomposites based on silver nanoparticles stabilized with amine-containing polyorganosiloxane polymers showed antimicrobial activity against Bacillus subtilis and Escherichia coli.
Keywords: silver nanoparticles; antimicrobial activity; polyaminopropylsiloxanes; hyperbranched molecular architectures; metal–vapor synthesis; X-ray photoelectron spectroscopy silver nanoparticles; antimicrobial activity; polyaminopropylsiloxanes; hyperbranched molecular architectures; metal–vapor synthesis; X-ray photoelectron spectroscopy

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MDPI and ACS Style

Vasil’kov, A.; Migulin, D.; Naumkin, A.; Volkov, I.; Butenko, I.; Golub, A.; Sadykova, V.; Muzafarov, A. Hybrid Materials with Antimicrobial Properties Based on Hyperbranched Polyaminopropylalkoxysiloxanes Embedded with Ag Nanoparticles. Pharmaceutics 2023, 15, 809. https://doi.org/10.3390/pharmaceutics15030809

AMA Style

Vasil’kov A, Migulin D, Naumkin A, Volkov I, Butenko I, Golub A, Sadykova V, Muzafarov A. Hybrid Materials with Antimicrobial Properties Based on Hyperbranched Polyaminopropylalkoxysiloxanes Embedded with Ag Nanoparticles. Pharmaceutics. 2023; 15(3):809. https://doi.org/10.3390/pharmaceutics15030809

Chicago/Turabian Style

Vasil’kov, Alexander, Dmitry Migulin, Alexander Naumkin, Ilya Volkov, Ivan Butenko, Alexandre Golub, Vera Sadykova, and Aziz Muzafarov. 2023. "Hybrid Materials with Antimicrobial Properties Based on Hyperbranched Polyaminopropylalkoxysiloxanes Embedded with Ag Nanoparticles" Pharmaceutics 15, no. 3: 809. https://doi.org/10.3390/pharmaceutics15030809

APA Style

Vasil’kov, A., Migulin, D., Naumkin, A., Volkov, I., Butenko, I., Golub, A., Sadykova, V., & Muzafarov, A. (2023). Hybrid Materials with Antimicrobial Properties Based on Hyperbranched Polyaminopropylalkoxysiloxanes Embedded with Ag Nanoparticles. Pharmaceutics, 15(3), 809. https://doi.org/10.3390/pharmaceutics15030809

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