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Pharmaceutics
Volume 15
Issue 2
10.3390/pharmaceutics15020616
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Article

In Vitro Study of Biological Activity of Tanacetum vulgare Extracts

by
Olga Babich
1,
Viktoria Larina
1,
Olesia Krol
1,
Elena Ulrikh
2,
Stanislav Sukhikh
1,
Maxim A. Gureev
3,
Alexander Prosekov
4 and
Svetlana Ivanova
5,6,*
1
Research and Education Center “Industrial Biotechnologies”, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, Kaliningrad 236016, Russia
2
Institute of Agroengineering and Food System, Kaliningrad State Technical University, Soviet Avenue 1, Kaliningrad 236022, Russia
3
Center of Bio- and Chemoinformatics, I.M. Sechenov First Moscow State Medical University, Trubetskaya 8/2, Moscow 119991, Russia
4
Laboratory of Biocatalysis, Kemerovo State University, Krasnaya Street 6, Kemerovo 650043, Russia
5
Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Krasnaya Street 6, Kemerovo 650043, Russia
6
Department of TNSMD Theory and Methods, Kemerovo State University, Krasnaya Street, 6, Kemerovo 650043, Russia
*
Author to whom correspondence should be addressed.
Pharmaceutics 2023, 15(2), 616; https://doi.org/10.3390/pharmaceutics15020616
Submission received: 17 January 2023 / Revised: 5 February 2023 / Accepted: 10 February 2023 / Published: 12 February 2023
(This article belongs to the Special Issue Bioactive Molecules from Plants: Discovery and Pharmaceutical Applications (Volume II))
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Abstract

Tanacetum vulgare is an herbaceous plant widely used in folk medicine. It is rich in phenolic acids and flavonoids, which have pharmacological and medicinal properties, such as anthelmintic, antispasmodic, tonic, antidiabetic, diuretic, and antihypertensive. This study aimed to confirm the presence of biologically active substances in Tanacetum vulgare and to determine the pharmacological spectrum of biological activity of Tanacetum vulgare extract components. When preparing Tanacetum vulgare extracts, the highest yield was observed when using the maceration method with a mixture of solvents methanol + trifluoroacetic acid (22.65 ± 0.68%). The biologically active substances in Tanacetum vulgare extract samples were determined using high-performance liquid chromatography. Biologically active substances such as luteolin-7-glucoside (550.80 mg/kg), chlorogenic acid (5945.40 mg/kg), and rosmarinic acid (661.31 mg/kg) were identified. Their structures were determined. The experiments have confirmed the antioxidant and antibacterial activities. Secondary metabolites of Tanacetum vulgare extracts have been found to have previously unknown biological activity types; experimental confirmation of their existence will advance phytochemical research and lead to the development of new drugs.
Keywords: Tanacetum vulgare; biological activity; extracts; biologically active substances; high-performance liquid chromatography Tanacetum vulgare; biological activity; extracts; biologically active substances; high-performance liquid chromatography

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MDPI and ACS Style

Babich, O.; Larina, V.; Krol, O.; Ulrikh, E.; Sukhikh, S.; Gureev, M.A.; Prosekov, A.; Ivanova, S. In Vitro Study of Biological Activity of Tanacetum vulgare Extracts. Pharmaceutics 2023, 15, 616. https://doi.org/10.3390/pharmaceutics15020616

AMA Style

Babich O, Larina V, Krol O, Ulrikh E, Sukhikh S, Gureev MA, Prosekov A, Ivanova S. In Vitro Study of Biological Activity of Tanacetum vulgare Extracts. Pharmaceutics. 2023; 15(2):616. https://doi.org/10.3390/pharmaceutics15020616

Chicago/Turabian Style

Babich, Olga, Viktoria Larina, Olesia Krol, Elena Ulrikh, Stanislav Sukhikh, Maxim A. Gureev, Alexander Prosekov, and Svetlana Ivanova. 2023. "In Vitro Study of Biological Activity of Tanacetum vulgare Extracts" Pharmaceutics 15, no. 2: 616. https://doi.org/10.3390/pharmaceutics15020616

APA Style

Babich, O., Larina, V., Krol, O., Ulrikh, E., Sukhikh, S., Gureev, M. A., Prosekov, A., & Ivanova, S. (2023). In Vitro Study of Biological Activity of Tanacetum vulgare Extracts. Pharmaceutics, 15(2), 616. https://doi.org/10.3390/pharmaceutics15020616

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