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Volume 15
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Article

Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug

by
Maider Ugalde-Arbizu
1,2,3,
John Jairo Aguilera-Correa
2,4,*,
Victoria García-Almodóvar
3,
Karina Ovejero-Paredes
5,6,
Diana Díaz-García
3,
Jaime Esteban
2,4,
Paulina L. Páez
7,
Sanjiv Prashar
3,
Eider San Sebastian
1,
Marco Filice
5,6,* and
Santiago Gómez-Ruiz
3,*
1
Departamento de Química Aplicada, Facultad de Química, Euskal Herriko Unibertsitatea (UPV/EHU), Paseo Manuel Lardizabal 3, 20018 Donostia San Sebastián, Spain
2
Clinical Microbiology Department, IIS-Fundación Jiménez Diaz, UAM, Avenida Reyes 15 Católicos 2, 28037 Madrid, Spain
3
COMET-NANO Group, Departamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, C/Tulipán s/n, 28933 Móstoles, Spain
4
CIBERINFEC-CIBER de Enfermedades Infecciosas, 28029 Madrid, Spain
5
Nanobiotechnology for Life Sciences Group, Department of Chemistry in Pharmaceutical Sciences, Faculty of Pharmacy, Universidad Complutense de Madrid (UCM), Plaza Ramón y Cajal s/n, 28040 Madrid, Spain
6
Microscopy and Dynamic Imaging Unit, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Calle Melchor Fernandez Almagro 3, 28029 Madrid, Spain
7
Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2023, 15(2), 560; https://doi.org/10.3390/pharmaceutics15020560
Submission received: 23 December 2022 / Revised: 24 January 2023 / Accepted: 1 February 2023 / Published: 7 February 2023
(This article belongs to the Special Issue Drug Delivery of Natural Active Principles: Focus on Topical and Oral Applications)
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Abstract

Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), were identified as excellent anticancer agents against triple negative breast cancer, one of the most diagnosed and aggressive cancerous tumors, with very poor prognosis. Notably, compound 2-MSN-Sn shows selectivity for cancer cells and excellent luminescent properties detectable by imaging techniques once internalized. The same compound is also able to interact with and nearly eradicate biofilms of Staphylococcus aureus, the most common bacteria isolated from chronic wounds and burns, whose treatment is a clinical challenge. 2-MSN-Sn is efficiently internalized by bacteria in a biofilm state and destroys the latter through reactive oxygen species (ROS) generation. Its internalization by bacteria was also efficiently monitored by fluorescence imaging. Since silica nanoparticles are particularly suitable for oral or topical administration, and considering both its anticancer and antibacterial activity, 2-MSN-Sn represents a new dual-condition theranostic agent, based primarily on natural products or their derivatives and with only a minimum amount of a novel metallodrug.
Keywords: cancer; bacteria; biofilm; oral; topical; luminescence; theranosis; S. aureus; biofilm; wound healing cancer; bacteria; biofilm; oral; topical; luminescence; theranosis; S. aureus; biofilm; wound healing
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MDPI and ACS Style

Ugalde-Arbizu, M.; Aguilera-Correa, J.J.; García-Almodóvar, V.; Ovejero-Paredes, K.; Díaz-García, D.; Esteban, J.; Páez, P.L.; Prashar, S.; San Sebastian, E.; Filice, M.; et al. Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug. Pharmaceutics 2023, 15, 560. https://doi.org/10.3390/pharmaceutics15020560

AMA Style

Ugalde-Arbizu M, Aguilera-Correa JJ, García-Almodóvar V, Ovejero-Paredes K, Díaz-García D, Esteban J, Páez PL, Prashar S, San Sebastian E, Filice M, et al. Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug. Pharmaceutics. 2023; 15(2):560. https://doi.org/10.3390/pharmaceutics15020560

Chicago/Turabian Style

Ugalde-Arbizu, Maider, John Jairo Aguilera-Correa, Victoria García-Almodóvar, Karina Ovejero-Paredes, Diana Díaz-García, Jaime Esteban, Paulina L. Páez, Sanjiv Prashar, Eider San Sebastian, Marco Filice, and et al. 2023. "Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug" Pharmaceutics 15, no. 2: 560. https://doi.org/10.3390/pharmaceutics15020560

APA Style

Ugalde-Arbizu, M., Aguilera-Correa, J. J., García-Almodóvar, V., Ovejero-Paredes, K., Díaz-García, D., Esteban, J., Páez, P. L., Prashar, S., San Sebastian, E., Filice, M., & Gómez-Ruiz, S. (2023). Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug. Pharmaceutics, 15(2), 560. https://doi.org/10.3390/pharmaceutics15020560

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