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Pharmaceutics
Volume 15
Issue 2
10.3390/pharmaceutics15020319
Review Report
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Review
Peer-Review Record

18F-fluorodeoxyglucose (18F-FDG) Functionalized Gold Nanoparticles (GNPs) for Plasmonic Photothermal Ablation of Cancer: A Review

Pharmaceutics 2023, 15(2), 319; https://doi.org/10.3390/pharmaceutics15020319
by Mariano Pontico 1,†, Miriam Conte 1,†, Francesca Petronella 2, Viviana Frantellizzi 1,*, Maria Silvia De Feo 1, Dario Di Luzio 1, Roberto Pani 3, Giuseppe De Vincentis 1 and Luciano De Sio 3
Reviewer 1:
Vadde Ramu
Pharmaceutics 2023, 15(2), 319; https://doi.org/10.3390/pharmaceutics15020319
Submission received: 16 December 2022 / Revised: 5 January 2023 / Accepted: 16 January 2023 / Published: 18 January 2023
(This article belongs to the Special Issue Advances in the Development and Application of Targeted Radiopharmaceuticals for Cancer Management)

Round 1

Reviewer 1 Report

This review article reported by Mariano et.al. will give very nice view of possible future applications and limitations of radio labelled Gold Nano Particles for the use of PPT/PTT. This review article contains lot of information on GNPs modified with FDG-related molecules for biomedical applications. I would recommend accepting this publication after answering the following questions.

1.       PPT abbreviation has not given while using it for the first time in line 288.

2.       Chemical structure of 2-(18F)fluoro-2-deoxy-D-glucose is missing.

3.       This review is only having one chemdraw figure that makes readers exhausted reading only the text. Authors left it to the reader’s imagination. It would make readers life easier when they read review along with some example figures of Gold Nano-particles previously reported in the literature.

Author Response

Thank you for the comment 1, the PTT abbreviation has been explicated with the term “Plasmonic photothermal therapy” and better explained in line 113.

Thank you for the comment 2, the chemical structure (yet explicated in the text in line 289) has been added as figure 1.

Thank you for the suggestion. More figures have been added.

Author Response File: Author Response.docx

Reviewer 2 Report

see the attached file

Comments for author File: Comments.doc

Author Response

I would thank you for the suggestion, the term “a review” has been added in the end of the title.

I would thank you for the second advice, all the abbreviations have been identified.

Thank you for the comment 3, the aim has been better clarified.

Thank you for the comment 4, the acronyms have been explicated.

I would thank you for the last observation. The conclusion was represented by the last paragraph, in particular the last lines 605-609 “Indeed, further studies…. treatment modalities.“. Actually it was not clearly expressed. For a better clarification, the title has been changed in “10. Future perspectives and disclosure “

Author Response File: Author Response.docx

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