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Volume 14
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Article

Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide

by
Shi Guo
1,†,
Zhengmei Song
1,†,
Ding-Kun Ji
1,‡,
Giacomo Reina
1,§,
Jean-Daniel Fauny
1,
Yuta Nishina
2,3,
Cécilia Ménard-Moyon
1 and
Alberto Bianco
1,*
1
CNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, 67000 Strasbourg, France
2
Graduate School of Natural Science and Technology, Okayama University, Tsushimanaka, Kita-ku, Okayama 700-8530, Japan
3
Research Core for Interdisciplinary Sciences, Okayama University, Tsushimanaka, Kita-ku, Okayama 700-8530, Japan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
Current address: Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
§
Current address: Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Pharmaceutics 2022, 14(7), 1365; https://doi.org/10.3390/pharmaceutics14071365
Submission received: 6 May 2022 / Revised: 13 June 2022 / Accepted: 23 June 2022 / Published: 28 June 2022
(This article belongs to the Special Issue Development of Novel Nanomedicines for Combination Therapy and Theranostic Applications)
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Abstract

Graphene oxide (GO) is one of the most studied nanomaterials in many fields, including the biomedical field. Most of the nanomaterials developed for drug delivery and phototherapies are based on noncovalent approaches that lead to an unspecific release of physisorbed molecules in complex biological environments. Therefore, preparing covalently functionalized GO using straightforward and versatile methods is highly valuable. Phototherapies, including photothermal therapy (PTT) and photodynamic therapy (PDT), have shown great potential as effective therapeutic approaches against cancer. To overcome the limits of a single method, the combination of PTT and PDT can lead to a combined effect with a higher therapeutic efficiency. In this work, we prepare a folic acid (FA) and chlorin e6 (Ce6) double-functionalized GO for combined targeted PTT/PDT. This conjugate can penetrate rapidly into cancer cells and macrophages. A combined effect of PTT and PDT is observed, leading to a higher killing efficiency toward different types of cells involved in cancer and other diseases. Our work provides a simple protocol to prepare multifunctional platforms for the treatment of various diseases.
Keywords: Carbon nanomaterials; phototherapy; targeting; chlorin e6; macrophages Carbon nanomaterials; phototherapy; targeting; chlorin e6; macrophages

Share and Cite

MDPI and ACS Style

Guo, S.; Song, Z.; Ji, D.-K.; Reina, G.; Fauny, J.-D.; Nishina, Y.; Ménard-Moyon, C.; Bianco, A. Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide. Pharmaceutics 2022, 14, 1365. https://doi.org/10.3390/pharmaceutics14071365

AMA Style

Guo S, Song Z, Ji D-K, Reina G, Fauny J-D, Nishina Y, Ménard-Moyon C, Bianco A. Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide. Pharmaceutics. 2022; 14(7):1365. https://doi.org/10.3390/pharmaceutics14071365

Chicago/Turabian Style

Guo, Shi, Zhengmei Song, Ding-Kun Ji, Giacomo Reina, Jean-Daniel Fauny, Yuta Nishina, Cécilia Ménard-Moyon, and Alberto Bianco. 2022. "Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide" Pharmaceutics 14, no. 7: 1365. https://doi.org/10.3390/pharmaceutics14071365

APA Style

Guo, S., Song, Z., Ji, D.-K., Reina, G., Fauny, J.-D., Nishina, Y., Ménard-Moyon, C., & Bianco, A. (2022). Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide. Pharmaceutics, 14(7), 1365. https://doi.org/10.3390/pharmaceutics14071365

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