Peptide-Based [68Ga]Ga Labeled PET Tracer for Tumor Imaging by Targeting Tumor-Associated Macrophages
Abstract
:1. Introduction
2. Materials and Methods
2.1. Synthesis of DOTA-M2pep and Radiolabeling
2.2. Cell Culture and Animal Model
2.3. In Vitro Uptake and Binding Assay
2.4. Micro-PET Imaging
2.5. Biodistribution Studies
2.6. Statistical Analysis
3. Results
3.1. Synthesis, Radiolabeling and Stability
3.2. In Vitro Uptake and Binding Assay
3.3. Micro-PET Imaging
3.4. Biodistribution Studies
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
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Huang, M.; Wang, R.; Li, M.; Cai, H.; Tian, R. Peptide-Based [68Ga]Ga Labeled PET Tracer for Tumor Imaging by Targeting Tumor-Associated Macrophages. Pharmaceutics 2022, 14, 2511. https://doi.org/10.3390/pharmaceutics14112511
Huang M, Wang R, Li M, Cai H, Tian R. Peptide-Based [68Ga]Ga Labeled PET Tracer for Tumor Imaging by Targeting Tumor-Associated Macrophages. Pharmaceutics. 2022; 14(11):2511. https://doi.org/10.3390/pharmaceutics14112511
Chicago/Turabian StyleHuang, Mingxing, Rang Wang, Mufeng Li, Huawei Cai, and Rong Tian. 2022. "Peptide-Based [68Ga]Ga Labeled PET Tracer for Tumor Imaging by Targeting Tumor-Associated Macrophages" Pharmaceutics 14, no. 11: 2511. https://doi.org/10.3390/pharmaceutics14112511