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Pharmaceutics
Volume 13
Issue 8
10.3390/pharmaceutics13081116
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Article
Peer-Review Record

Preparation of Magnetic–Luminescent Bifunctional Rapeseed Pod-Like Drug Delivery System for Sequential Release of Dual Drugs†

Pharmaceutics 2021, 13(8), 1116; https://doi.org/10.3390/pharmaceutics13081116
by Junwei Xu 1, Yunxue Jia 1, Meili Liu 1, Xuenan Gu 1, Ping Li 1,* and Yubo Fan 1,2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Pharmaceutics 2021, 13(8), 1116; https://doi.org/10.3390/pharmaceutics13081116
Submission received: 28 May 2021 / Revised: 4 July 2021 / Accepted: 8 July 2021 / Published: 22 July 2021
(This article belongs to the Special Issue Selected Papers from the 1st International Electronic Conference on Pharmaceutics (IECP 2020))

Round 1

Reviewer 1 Report

  1. Abstract; The results of the study should be highlighted. Additionally, some quantity results must be added to this section.
  2. Introduction; Line 56-58; Depending on the contact of the nanorod with the cell surface, the internalization process may be difficult. It is recommended to read the following article for more information: https://doi.org/10.1016/j.nantod.2020.101057
  3. Introduction; Line 71-74; Slow-release (Sustained release) can increase the effects of multi-drug resistance. I suggest you read the following article: https://doi.org/10.1016/j.jconrel.2020.08.012
  4. What is the main contribution of this manuscript compared to previously published ones?
  5. Add more discussion about the results extracted from figures. This is one of the main shortcomings of this manuscript.
  6. Results-Morphological observation; Line 312-315; The size of the carrier is large, so limited its applications, especially in anti-cancer applications. Discuss in this regard.
  7. Results-Drug release evaluation:
  • There is no logical explanation for what happened. 
  • In response to which stimulus is the drug released?
  • If released without response, the carrier is shown to be unstable, which will lead to various side effects.
  • In Figure 6 (B-E), the vertical axis caption is not "drug release rate" but "percentage of drug released". However, it is suggested that additional explanations be added regarding the release rate.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Please see attachment

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The comments are applied in an acceptable way. Now, the paper has the worth of publication. 

Author Response

Thank you very much for your careful review and evaluation of this work. 

Reviewer 2 Report

The authors are thanked to have address the comments of the reviewers strengthening their manuscript. I would suggest publication of the revised manuscript after the minor modifications listed below:

  • line 44: ”response” instead of “responce”
  • line 545: please do not start a sentence by “and”
  • line 626: please use only significant numbers: 136 ± 38 nm for example (same for lines 635, 645, 721-723, 776, 780, 917-918, 988, 995-996, 1003

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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