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Article

Preparation of Magnetic–Luminescent Bifunctional Rapeseed Pod-Like Drug Delivery System for Sequential Release of Dual Drugs

by 1, 1, 1, 1, 1,* and 1,2,*
1
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
2
School of Medical Science and Engineering, Beihang University, Beijing 100191, China
*
Authors to whom correspondence should be addressed.
This paper is an extended version of paper published in the 1st International Electronic Conference on Pharmaceutics 2020, Online, 1–15 December 2020; Xu, J.; Li, P.; Fan, Y. Preparation of Magnetic-Fluorescent Bifunctional Microrods as a Drug Delivery System via One-Step Electrospraying. (doi:10.3390/IECP2020-08646).
Academic Editors: Elisabetta Gavini and Andrea Erxleben
Pharmaceutics 2021, 13(8), 1116; https://doi.org/10.3390/pharmaceutics13081116
Received: 28 May 2021 / Revised: 4 July 2021 / Accepted: 8 July 2021 / Published: 22 July 2021
Drug delivery systems (DDSs) limited to a single function or single-drug loading are struggling to meet the requirements of clinical medical applications. It is of great significance to fabricate DDSs with multiple functions such as magnetic targeting or fluorescent labeling, as well as with multiple-drug loading for enhancing drug efficacy and accelerating actions. In this study, inspired by the dual-chamber structure of rapeseed pods, biomimetic magnetic–luminescent bifunctional drug delivery carriers (DDCs) of 1.9 ± 0.3 μm diameter and 19.6 ± 4.4 μm length for dual drug release were fabricated via double-needle electrospraying. Morphological images showed that the rapeseed pod-like DDCs had a rod-like morphology and Janus dual-chamber structure. Magnetic nanoparticles and luminescent materials were elaborately designed to be dispersed in two different chambers to endow the DDCs with excellent magnetic and luminescent properties. Synchronously, the Janus structure of DDCs promoted the luminescent intensity by at least threefold compared to single-chamber DDCs. The results of the hemolysis experiment and cytotoxicity assay suggested the great blood and cell compatibilities of DDCs. Further inspired by the core–shell structure of rapeseeds containing oil wrapped in rapeseed pods, DDCs were fabricated to carry benzimidazole molecules and [email protected] nanoparticles in different chambers, realizing the sequential release of benzimidazole within 12 h and of doxorubicin from day 3 to day 18. These rapeseed pod-like DDSs with excellent magnetic and luminescent properties and sequential release of dual drugs have potential for biomedical applications such as targeted drug delivery, bioimaging, and sustained treatment of diseases. View Full-Text
Keywords: rapeseed pod-like drug delivery system; electrospray; magnetic–luminescent bifunctional drug delivery carrier; dual drugs; sequential release rapeseed pod-like drug delivery system; electrospray; magnetic–luminescent bifunctional drug delivery carrier; dual drugs; sequential release
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MDPI and ACS Style

Xu, J.; Jia, Y.; Liu, M.; Gu, X.; Li, P.; Fan, Y. Preparation of Magnetic–Luminescent Bifunctional Rapeseed Pod-Like Drug Delivery System for Sequential Release of Dual Drugs. Pharmaceutics 2021, 13, 1116. https://doi.org/10.3390/pharmaceutics13081116

AMA Style

Xu J, Jia Y, Liu M, Gu X, Li P, Fan Y. Preparation of Magnetic–Luminescent Bifunctional Rapeseed Pod-Like Drug Delivery System for Sequential Release of Dual Drugs. Pharmaceutics. 2021; 13(8):1116. https://doi.org/10.3390/pharmaceutics13081116

Chicago/Turabian Style

Xu, Junwei, Yunxue Jia, Meili Liu, Xuenan Gu, Ping Li, and Yubo Fan. 2021. "Preparation of Magnetic–Luminescent Bifunctional Rapeseed Pod-Like Drug Delivery System for Sequential Release of Dual Drugs" Pharmaceutics 13, no. 8: 1116. https://doi.org/10.3390/pharmaceutics13081116

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