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Article

Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol

1
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea
2
Department of Material Science and Engineering, Seoul National University, Seoul 08826, Korea
3
College of Pharmacy, Chungnam National University, Daejeon 34134, Korea
4
Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Korea
5
R&D Center, BOBSNU, Suwon 16229, Korea
6
Department of Biomedicine, Health & Life Convergence Sciences (BK21 Four), College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Korea
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2020, 12(9), 845; https://doi.org/10.3390/pharmaceutics12090845
Received: 22 July 2020 / Revised: 27 August 2020 / Accepted: 1 September 2020 / Published: 3 September 2020
(This article belongs to the Special Issue Natural Products in Drug Delivery Systems)
Orobol is one of the major soy isoflavones, and has been reported to have various pharmacological activities, including an anti-skin-aging effect. However, since it has low solubility in water and physicochemical instability, the formulation of orobol for delivery into the dermal layer of the skin could be challenging. The objective of this study was to prepare lipid nanoparticles formulations of orobol to enhance its stability as well as its deposition into the skin. Formulations of orobol-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were characterized in terms of their mean particle size, entrapment efficiency, and morphology. The nano-sized spherical NLCs formulations maintained the stability of orobol for up to 28 days. Moreover, the NLCs formulation significantly increased the in vitro deposition of orobol into both Strat-M membranes and human cadaver skin compared with the other formulations. Additionally, the NLCs formulation did not cause significant skin irritation in clinical study. These results demonstrate that a shea butter-based NLC formulation could be a promising and safe carrier system for improving the stability of orobol and enhancing its topical skin delivery. View Full-Text
Keywords: orobol; nanostructured lipid carrier (NLC); physicochemical stability; Strat-M membrane; human cadaver skin; topical skin delivery; skin irritation orobol; nanostructured lipid carrier (NLC); physicochemical stability; Strat-M membrane; human cadaver skin; topical skin delivery; skin irritation
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MDPI and ACS Style

Kim, M.-H.; Jeon, Y.-E.; Kang, S.; Lee, J.-Y.; Lee, K.W.; Kim, K.-T.; Kim, D.-D. Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol. Pharmaceutics 2020, 12, 845. https://doi.org/10.3390/pharmaceutics12090845

AMA Style

Kim M-H, Jeon Y-E, Kang S, Lee J-Y, Lee KW, Kim K-T, Kim D-D. Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol. Pharmaceutics. 2020; 12(9):845. https://doi.org/10.3390/pharmaceutics12090845

Chicago/Turabian Style

Kim, Min-Hwan, Yae-Eun Jeon, Soobeen Kang, Jae-Young Lee, Ki W. Lee, Ki-Taek Kim, and Dae-Duk Kim. 2020. "Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol" Pharmaceutics 12, no. 9: 845. https://doi.org/10.3390/pharmaceutics12090845

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