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Open AccessReview

Mucoadhesive Electrospun Fibre-Based Technologies for Oral Medicine

1
School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK
2
Department of Chemistry, Brook Hill, University of Sheffield, Sheffield S3 7HF, UK
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(6), 504; https://doi.org/10.3390/pharmaceutics12060504
Received: 11 May 2020 / Revised: 28 May 2020 / Accepted: 30 May 2020 / Published: 2 June 2020
(This article belongs to the Special Issue Bioadhesive Systems for Topical Application)
Oral disease greatly affects quality of life, as the mouth is required for a wide range of activities including speech, food and liquid consumption. Treatment of oral disease is greatly limited by the dose forms that are currently available, which suffer from short contact times, poor site specificity, and sensitivity to mechanical stimulation. Mucoadhesive devices prepared using electrospinning offer the potential to address these challenges by allowing unidirectional site-specific drug delivery through intimate contact with the mucosa and with high surface areas to facilitate drug release. This review will discuss the range of electrospun mucoadhesive devices that have recently been reported to address oral inflammatory diseases, pain relief, and infections, as well as new treatments that are likely to be enabled by this technology in the future. View Full-Text
Keywords: bioadhesion; mucosa; local therapy; electrospinning; oral cavity; drug delivery; inflammation; infections; pain relief bioadhesion; mucosa; local therapy; electrospinning; oral cavity; drug delivery; inflammation; infections; pain relief
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MDPI and ACS Style

Edmans, J.G.; Clitherow, K.H.; Murdoch, C.; Hatton, P.V.; Spain, S.G.; Colley, H.E. Mucoadhesive Electrospun Fibre-Based Technologies for Oral Medicine. Pharmaceutics 2020, 12, 504. https://doi.org/10.3390/pharmaceutics12060504

AMA Style

Edmans JG, Clitherow KH, Murdoch C, Hatton PV, Spain SG, Colley HE. Mucoadhesive Electrospun Fibre-Based Technologies for Oral Medicine. Pharmaceutics. 2020; 12(6):504. https://doi.org/10.3390/pharmaceutics12060504

Chicago/Turabian Style

Edmans, Jake G.; Clitherow, Katharina H.; Murdoch, Craig; Hatton, Paul V.; Spain, Sebastian G.; Colley, Helen E. 2020. "Mucoadhesive Electrospun Fibre-Based Technologies for Oral Medicine" Pharmaceutics 12, no. 6: 504. https://doi.org/10.3390/pharmaceutics12060504

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