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Open AccessArticle

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

1
FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK
2
Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29–39 Brunswick Square, London WC1N 1AX, UK
3
Losan Pharma GmbH, Otto-Hahn-Strasse 13, 79395 Neuenburg, Germany
4
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma Group (GI-1645), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2020, 12(2), 110; https://doi.org/10.3390/pharmaceutics12020110
Received: 19 December 2019 / Revised: 16 January 2020 / Accepted: 20 January 2020 / Published: 30 January 2020
(This article belongs to the Collection 3D Printing and Bioprinting Applications in Pharmaceutics)
The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient. View Full-Text
Keywords: three-dimensional printing; 3D printed drug products; printing pharmaceuticals; additive manufacturing; rapid prototyping; orally disintegrating tablets (ODTs); orally disintegrating printlets (ODPs); taste masking; personalized medicines three-dimensional printing; 3D printed drug products; printing pharmaceuticals; additive manufacturing; rapid prototyping; orally disintegrating tablets (ODTs); orally disintegrating printlets (ODPs); taste masking; personalized medicines
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MDPI and ACS Style

Allahham, N.; Fina, F.; Marcuta, C.; Kraschew, L.; Mohr, W.; Gaisford, S.; Basit, A.W.; Goyanes, A. Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron. Pharmaceutics 2020, 12, 110. https://doi.org/10.3390/pharmaceutics12020110

AMA Style

Allahham N, Fina F, Marcuta C, Kraschew L, Mohr W, Gaisford S, Basit AW, Goyanes A. Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron. Pharmaceutics. 2020; 12(2):110. https://doi.org/10.3390/pharmaceutics12020110

Chicago/Turabian Style

Allahham, Nour; Fina, Fabrizio; Marcuta, Carmen; Kraschew, Lilia; Mohr, Wolfgang; Gaisford, Simon; Basit, Abdul W.; Goyanes, Alvaro. 2020. "Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron" Pharmaceutics 12, no. 2: 110. https://doi.org/10.3390/pharmaceutics12020110

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