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Article

Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching

1
DNRF and Villum Fonden Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, IDUN, DTU Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
2
National Centre of Nano Fabrication and Characterization, DTU Nanolab, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
3
Department of Health Technology, DTU Health Tech, Technical University of Denmark, 2800 Kgs. Lynby, Denmark
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(11), 1050; https://doi.org/10.3390/pharmaceutics12111050
Received: 2 October 2020 / Revised: 27 October 2020 / Accepted: 28 October 2020 / Published: 3 November 2020
(This article belongs to the Special Issue Design of Novel Polymeric Systems for Controlled Drug Delivery)
Microcontainers are reservoir-based advanced drug delivery systems (DDS) that have proven to increase the bioavailibity of the small-molecule drugs, targeting of biomolecules, protection of vaccines and improved treatment of Pseudomonas aeruginosa. However, high-throughput loading of these micron-sized devices with drug has been challenging. Hot punching is a new technique that is a fast, simple and single-step process where the microdevices are themselves used as mold to punch biocompatible and biodegradable drug-polymer films, thereby loading the containers. Here, we investigate the effect of hot punching on the drug distribution as well as drug release from the loaded drug-polymer matrices. Zero-order sustained drug release is observed for the model drug Furosemide embedded in biodegradable polymer, Poly-ε-caprolactone, which is attributed to the unique spatial distribution of Furosemide during the loading process. View Full-Text
Keywords: biocompatible and biodegradable polymer; hot punching; oral drug delivery; spin coating; controlled release; zero-order biocompatible and biodegradable polymer; hot punching; oral drug delivery; spin coating; controlled release; zero-order
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MDPI and ACS Style

Petersen, R.S.; Nielsen, L.H.; Rindzevicius, T.; Boisen, A.; Keller, S.S. Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching. Pharmaceutics 2020, 12, 1050. https://doi.org/10.3390/pharmaceutics12111050

AMA Style

Petersen RS, Nielsen LH, Rindzevicius T, Boisen A, Keller SS. Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching. Pharmaceutics. 2020; 12(11):1050. https://doi.org/10.3390/pharmaceutics12111050

Chicago/Turabian Style

Petersen, Ritika S.; Nielsen, Line H.; Rindzevicius, Tomas; Boisen, Anja; Keller, Stephan S. 2020. "Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching" Pharmaceutics 12, no. 11: 1050. https://doi.org/10.3390/pharmaceutics12111050

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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