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Article

Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching

1
DNRF and Villum Fonden Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, IDUN, DTU Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
2
National Centre of Nano Fabrication and Characterization, DTU Nanolab, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
3
Department of Health Technology, DTU Health Tech, Technical University of Denmark, 2800 Kgs. Lynby, Denmark
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(11), 1050; https://doi.org/10.3390/pharmaceutics12111050
Received: 2 October 2020 / Revised: 27 October 2020 / Accepted: 28 October 2020 / Published: 3 November 2020
(This article belongs to the Special Issue Design of Novel Polymeric Systems for Controlled Drug Delivery)
Microcontainers are reservoir-based advanced drug delivery systems (DDS) that have proven to increase the bioavailibity of the small-molecule drugs, targeting of biomolecules, protection of vaccines and improved treatment of Pseudomonas aeruginosa. However, high-throughput loading of these micron-sized devices with drug has been challenging. Hot punching is a new technique that is a fast, simple and single-step process where the microdevices are themselves used as mold to punch biocompatible and biodegradable drug-polymer films, thereby loading the containers. Here, we investigate the effect of hot punching on the drug distribution as well as drug release from the loaded drug-polymer matrices. Zero-order sustained drug release is observed for the model drug Furosemide embedded in biodegradable polymer, Poly-ε-caprolactone, which is attributed to the unique spatial distribution of Furosemide during the loading process. View Full-Text
Keywords: biocompatible and biodegradable polymer; hot punching; oral drug delivery; spin coating; controlled release; zero-order biocompatible and biodegradable polymer; hot punching; oral drug delivery; spin coating; controlled release; zero-order
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MDPI and ACS Style

Petersen, R.S.; Nielsen, L.H.; Rindzevicius, T.; Boisen, A.; Keller, S.S. Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching. Pharmaceutics 2020, 12, 1050. https://doi.org/10.3390/pharmaceutics12111050

AMA Style

Petersen RS, Nielsen LH, Rindzevicius T, Boisen A, Keller SS. Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching. Pharmaceutics. 2020; 12(11):1050. https://doi.org/10.3390/pharmaceutics12111050

Chicago/Turabian Style

Petersen, Ritika S., Line H. Nielsen, Tomas Rindzevicius, Anja Boisen, and Stephan S. Keller. 2020. "Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching" Pharmaceutics 12, no. 11: 1050. https://doi.org/10.3390/pharmaceutics12111050

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