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Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

by Sang-Nam Lee 1,2,†, Jin-Ha Choi 1,†, Hyeon-Yeol Cho 1,* and Jeong-Woo Choi 1,*
1
Department of Chemical & Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-Gu, Seoul 04107, Korea
2
Uniance Gene Inc., 1107 Teilhard Hall, 35 Baekbeom-Ro, Mapo-Gu, Seoul 04107, Korea
*
Authors to whom correspondence should be addressed.
The authors contributed equally to this work.
Pharmaceutics 2020, 12(1), 50; https://doi.org/10.3390/pharmaceutics12010050 (registering DOI)
Received: 10 November 2019 / Revised: 31 December 2019 / Accepted: 6 January 2020 / Published: 7 January 2020
(This article belongs to the Special Issue Metallic Nanoparticles in Pharmaceutical Applications)
The biosensing platform is noteworthy for high sensitivity and precise detection of target analytes, which are related to the status of cells or specific diseases. The modification of the transducers with metallic nanoparticles (MNPs) has attracted attention owing to excellent features such as improved sensitivity and selectivity. Moreover, the incorporation of MNPs into biosensing systems may increase the speed and the capability of the biosensors. In this review, we introduce the current progress of the developed cell-based biosensors, cell chip, based on the unique physiochemical features of MNPs. Mainly, we focus on optical intra/extracellular biosensing methods, including fluorescence, localized surface plasmon resonance (LSPR), and surface-enhanced Raman spectroscopy (SERS) based on the coupling of MNPs. We believe that the topics discussed here are useful and able to provide a guideline in the development of new MNP-based cell chip platforms for pharmaceutical applications such as drug screening and toxicological tests in the near future. View Full-Text
Keywords: cell chip; metallic nanoparticles; biosensors; intracellular signal; extracellular signal; nondestructive monitoring cell chip; metallic nanoparticles; biosensors; intracellular signal; extracellular signal; nondestructive monitoring
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Lee, S.-N.; Choi, J.-H.; Cho, H.-Y.; Choi, J.-W. Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals. Pharmaceutics 2020, 12, 50.

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