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The Polymorphism of Drugs: New Approaches to the Synthesis of Nanostructured Polymorphs

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia
Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russia
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(1), 34;
Received: 7 November 2019 / Revised: 12 December 2019 / Accepted: 25 December 2019 / Published: 1 January 2020
(This article belongs to the Special Issue Drug Polymorphism and Dosage Form Design)
Among the significant problems of modern pharmacology are the low solubility and bioavailability of drugs. One way to resolve this problem is to obtain new polymorphic forms of drugs with improved physicochemical properties. Various approaches have been developed with this aim, including the preparation of co-crystals, the use of nanoparticles, or the use of compounds in the form of a salt. A promising direction in pharmacology concerns the production of new stable polymorphic structures. In this mini-review, we consider certain aspects of drug polymorphism, methods for the synthesis of polymorphs, and the stability, size, and transformation of crystalline polymorphs. Moreover, we summarize our results from several studies demonstrating the problems associated with the synthesis of new polymorphous modifications based on inert gases and cryotemperatures. The results indicate that the problems specific to drug polymorphisms have only been partly resolved, are of current interest, and require further development. View Full-Text
Keywords: polymorphism; poorly soluble drug; cryotemperature; cryosynthesis; nanoparticles polymorphism; poorly soluble drug; cryotemperature; cryosynthesis; nanoparticles
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Chistyakov, D.; Sergeev, G. The Polymorphism of Drugs: New Approaches to the Synthesis of Nanostructured Polymorphs. Pharmaceutics 2020, 12, 34.

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