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Open AccessArticle

Spatial Distribution of (R)-salbutamol in Rat Brain Following Nasal and Intravenous Administration Using DESI-MS

by Rui Zhang 1,†, Jie Wu 2,3,†, Siyu Liu 1, LiangJun Deng 1, Junhua Hu 1, Xi Chen 1 and Wen Tan 1,4,*
1
Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, Guangdong, China
2
School of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China
3
YZ Health-tech Inc., Hengqin District, Zhuhai 519000, Guangdong, China
4
Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Pharmaceutics 2020, 12(1), 35; https://doi.org/10.3390/pharmaceutics12010035
Received: 26 November 2019 / Revised: 25 December 2019 / Accepted: 27 December 2019 / Published: 2 January 2020
(This article belongs to the Special Issue Drug Delivery for Treatment of Neurodegenerative Diseases)
Recent studies have shown that β2-Adrenoreceptor is a regulator of the a-synuclein gene driving risk of Parkinson’s disease. The β2-AR agonist (R)-salbutamol, eutomer of rac-salbutamol, may hold therapeutic potential for Parkinson’s disease (PD) following nasal administration. In this study, we use desorption electrospray ionization mass spectrometry (DESI-MS) to analyze spatial distribution of (R)-salbutamol in rat brain following nasal and intravenous administration. Here, we report that (R)-salbutamol efficiently deliver to the brain and had more drug dosage exposure in rat’s brain through nasal route administration than that of intravenous route administration. In conclusion, administering (R)-salbutamol through nasal route of administration may hold advantages in improving spatial distribution and increased exposure of drug in brain. View Full-Text
Keywords: Parkinson’s disease; β2-adrenergic receptor; salbutamol; nasal administration; desorption electrospray ionization Parkinson’s disease; β2-adrenergic receptor; salbutamol; nasal administration; desorption electrospray ionization
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MDPI and ACS Style

Zhang, R.; Wu, J.; Liu, S.; Deng, L.; Hu, J.; Chen, X.; Tan, W. Spatial Distribution of (R)-salbutamol in Rat Brain Following Nasal and Intravenous Administration Using DESI-MS. Pharmaceutics 2020, 12, 35.

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