Next Article in Journal
The Polymorphism of Drugs: New Approaches to the Synthesis of Nanostructured Polymorphs
Next Article in Special Issue
Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced via Hot-Melt Extrusion and Fused Deposition Modeling 3D Printing
Previous Article in Journal
Analgesia Effect of Enteric Sustained-Release Tetrodotoxin Pellets in the Rat
Previous Article in Special Issue
3D-Printed Solid Dispersion Drug Products

Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs

Pharmaceutical Sciences Laboratory, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, Finland
Laboratory of Natural Materials Technology, Åbo Akademi University, Porthaninkatu 3, 20500 Turku, Finland
Laboratory of Industrial Physics, University of Turku, Vesilinnantie 5, 20500 Turku, Finland
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(1), 33;
Received: 16 November 2019 / Revised: 15 December 2019 / Accepted: 16 December 2019 / Published: 1 January 2020
(This article belongs to the Special Issue 3D Printing of Pharmaceuticals and Drug Delivery Devices)
Stencil printing is a commonly used printing method, but it has not previously been used for production of pharmaceuticals. The aim of this study was to explore whether stencil printing of drug containing polymer inks could be used to manufacture flexible dosage forms with acceptable mass and content uniformity. Formulation development was supported by physicochemical characterization of the inks and final dosage forms. The printing of haloperidol (HAL) discs was performed using a prototype stencil printer. Ink development comprised of investigations of ink rheology in combination with printability assessment. The results show that stencil printing can be used to manufacture HAL doses in the therapeutic treatment range for 6–17 year-old children. The therapeutic HAL dose was achieved for the discs consisting of 16% of hydroxypropyl methylcellulose (HPMC) and 1% of lactic acid (LA). The formulation pH remained above pH 4 and the results imply that the drug was amorphous. Linear dose escalation was achieved by an increase in aperture area of the print pattern, while keeping the stencil thickness fixed. Disintegration times of the orodispersible discs printed with 250 and 500 µm thick stencils were below 30 s. In conclusion, stencil printing shows potential as a manufacturing method of pharmaceuticals. View Full-Text
Keywords: stencil printing; pharmacoprinting; orodispersible discs; orodisperible films stencil printing; pharmacoprinting; orodispersible discs; orodisperible films
Show Figures

Graphical abstract

MDPI and ACS Style

Wickström, H.; Koppolu, R.; Mäkilä, E.; Toivakka, M.; Sandler, N. Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs. Pharmaceutics 2020, 12, 33.

AMA Style

Wickström H, Koppolu R, Mäkilä E, Toivakka M, Sandler N. Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs. Pharmaceutics. 2020; 12(1):33.

Chicago/Turabian Style

Wickström, Henrika, Rajesh Koppolu, Ermei Mäkilä, Martti Toivakka, and Niklas Sandler. 2020. "Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs" Pharmaceutics 12, no. 1: 33.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop