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Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems

Department of Chemistry, Fribourg University, Chemin du Musée 9, 1700 Fribourg, Switzerland
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Pharmaceutics 2019, 11(10), 537; https://doi.org/10.3390/pharmaceutics11100537
Received: 16 September 2019 / Revised: 4 October 2019 / Accepted: 10 October 2019 / Published: 15 October 2019
Unicellular diatom microalgae are a promising natural resource of porous biosilica. These microorganisms produce around their membrane a highly porous and extremely structured silica shell called frustule. Once harvested from living algae or from fossil sediments of diatomaceous earth, this biocompatible and non-toxic material offers an exceptional potential in the field of micro/nano-devices, drug delivery, theranostics, and other medical applications. The present review focused on the use of diatoms in the field of drug delivery systems, with the aim of presenting the different strategies implemented to improve the biophysical properties of this biosilica in terms of drug loading and release efficiency, targeted delivery, or site-specific binding capacity by surface functionalization. The development of composite materials involving diatoms for drug delivery applications is also described. View Full-Text
Keywords: diatom; drug delivery; biosilica; composite; natural; surface functionalization diatom; drug delivery; biosilica; composite; natural; surface functionalization
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MDPI and ACS Style

Delasoie, J.; Zobi, F. Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems. Pharmaceutics 2019, 11, 537.

AMA Style

Delasoie J, Zobi F. Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems. Pharmaceutics. 2019; 11(10):537.

Chicago/Turabian Style

Delasoie, Joachim; Zobi, Fabio. 2019. "Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems" Pharmaceutics 11, no. 10: 537.

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