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Pharmaceutics
Volume 10
Issue 4
10.3390/pharmaceutics10040185
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Article

Brief Effect of a Small Hydrophobic Drug (Cinnarizine) on the Physicochemical Characterisation of Niosomes Produced by Thin-Film Hydration and Microfluidic Methods

by
Li Key Yeo
,
Temidayo O. B. Olusanya
,
Cheng Shu Chaw
and
Amal Ali Elkordy
*
School of Pharmacy and Pharmaceutical Sciences, University of Sunderland, Sunderland SR1 3SD, UK
*
Author to whom correspondence should be addressed.
Pharmaceutics 2018, 10(4), 185; https://doi.org/10.3390/pharmaceutics10040185
Submission received: 20 July 2018 / Revised: 5 October 2018 / Accepted: 9 October 2018 / Published: 13 October 2018
(This article belongs to the Special Issue Non-Ionic Surfactant Vesicles for Drug Delivery)
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Abstract

Novel niosomal formulations containing cinnarizine were developed to enhance its drug characteristics. In this work, niosomes (non-ionic surfactant vesicles) were prepared by conventional thin-film hydration (TFH) and microfluidic (MF) methods with sorbitan monostearate (Span® 60), cholesterol, and co-surfactants (Cremophor® ELP, Cremophor® RH40 and Solutol® HS15) as key excipients. The aim was to study the effect of cinnarizine on the characteristics of different niosomal formulations manufactured by using different methods. For effective targeted oral drug delivery, the efficacy of niosomes for therapeutic applications is correlated to their physiochemical properties. Niosome vesicles prepared were characterised using dynamic light scattering technique and the morphology of niosomes dispersion was characterised using optical microscopy. Dialysis was carried out to purify niosome suspensions to determine drug loading and drug release studies was performed to study the potential use of niosomal systems for cinnarizine.
Keywords: niosome; cinnarizine; poorly water-soluble drug; thin-film hydration; microfluidic; co-surfactants niosome; cinnarizine; poorly water-soluble drug; thin-film hydration; microfluidic; co-surfactants
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MDPI and ACS Style

Yeo, L.K.; Olusanya, T.O.B.; Chaw, C.S.; Elkordy, A.A. Brief Effect of a Small Hydrophobic Drug (Cinnarizine) on the Physicochemical Characterisation of Niosomes Produced by Thin-Film Hydration and Microfluidic Methods. Pharmaceutics 2018, 10, 185. https://doi.org/10.3390/pharmaceutics10040185

AMA Style

Yeo LK, Olusanya TOB, Chaw CS, Elkordy AA. Brief Effect of a Small Hydrophobic Drug (Cinnarizine) on the Physicochemical Characterisation of Niosomes Produced by Thin-Film Hydration and Microfluidic Methods. Pharmaceutics. 2018; 10(4):185. https://doi.org/10.3390/pharmaceutics10040185

Chicago/Turabian Style

Yeo, Li Key, Temidayo O. B. Olusanya, Cheng Shu Chaw, and Amal Ali Elkordy. 2018. "Brief Effect of a Small Hydrophobic Drug (Cinnarizine) on the Physicochemical Characterisation of Niosomes Produced by Thin-Film Hydration and Microfluidic Methods" Pharmaceutics 10, no. 4: 185. https://doi.org/10.3390/pharmaceutics10040185

APA Style

Yeo, L. K., Olusanya, T. O. B., Chaw, C. S., & Elkordy, A. A. (2018). Brief Effect of a Small Hydrophobic Drug (Cinnarizine) on the Physicochemical Characterisation of Niosomes Produced by Thin-Film Hydration and Microfluidic Methods. Pharmaceutics, 10(4), 185. https://doi.org/10.3390/pharmaceutics10040185

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