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Pharmaceutics 2018, 10(3), 129; https://doi.org/10.3390/pharmaceutics10030129

Lysine Dendrigraft Nanocontainers. Influence of Topology on Their Size and Internal Structure

1
Faculty of Physics, St. Petersburg State University, Ulyanovskaya Str.1, Petrodvorets, 198504 St. Petersburg, Russia
2
St. Petersburg National University of Informational Technologies, Mechanics and Optics (ITMO University), Kronverksky pr.49, 197101 St. Petersburg, Russia
*
Author to whom correspondence should be addressed.
Received: 1 July 2018 / Revised: 29 July 2018 / Accepted: 8 August 2018 / Published: 13 August 2018
(This article belongs to the Special Issue Dendrimers in Nanomedical Applications: Update and Future Directions)
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Abstract

Poly-l-ysine dendrigrafts are promising systems for biomedical applications due to their biodegradability, biocompatibility, and similarity to dendrimers. There are many papers about the use of dendrigrafts as nanocontainers for drug delivery. At the same time, the number of studies about their physical properties is limited, and computer simulations of dendrigrafts are almost absent. This paper presents the results of a systematic molecular dynamics simulation study of third-generation lysine dendrigrafts with different topologies. The size and internal structures of the dendrigrafts were calculated. We discovered that the size of dendrigrafts of the same molecular weight depends on their topology. The shape of all studied dendrigrafts is close to spherical. Density profile of dendrigrafts depends on their topology. View Full-Text
Keywords: poly-l-lysine; dendrigrafts; molecular dynamics simulation poly-l-lysine; dendrigrafts; molecular dynamics simulation
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Okrugin, B.; Ilyash, M.; Markelov, D.; Neelov, I. Lysine Dendrigraft Nanocontainers. Influence of Topology on Their Size and Internal Structure. Pharmaceutics 2018, 10, 129.

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