Next Article in Journal
Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting
Previous Article in Journal / Special Issue
Preventing Crystal Agglomeration of Pharmaceutical Crystals Using Temperature Cycling and a Novel Membrane Crystallization Procedure for Seed Crystal Generation
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessReview
Pharmaceutics 2018, 10(1), 18;

Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs

Department of Pharmaceutical Technology, Aristotle University of Thessaloniki, 54351 Thessaloniki, Greece
Faculty of Engineering and Science, University of Greenwich at Medway, Kent ME4 4TB, UK
Author to whom correspondence should be addressed.
Received: 29 November 2017 / Revised: 2 January 2018 / Accepted: 10 January 2018 / Published: 25 January 2018
(This article belongs to the Special Issue Pharmaceutical Crystallisation Science and Engineering)
Full-Text   |   PDF [7324 KB, uploaded 25 January 2018]   |  


Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet the expected targets. In this article, an overview of pharmaceutical cocrystals will be presented, with an emphasis on the intermolecular interactions in cocrystals and the methods for their preparation. Furthermore, cocrystals of direct pharmaceutical interest, along with their in vitro properties and available in vivo data and characterization techniques are discussed, highlighting the potential of cocrystals as an attractive route for drug development. View Full-Text
Keywords: cocrystals; coformers; solid state properties; poorly soluble APIs cocrystals; coformers; solid state properties; poorly soluble APIs

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Karagianni, A.; Malamatari, M.; Kachrimanis, K. Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs. Pharmaceutics 2018, 10, 18.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top