Next Article in Journal
SGS3 Cooperates with RDR6 in Triggering Geminivirus-Induced Gene Silencing and in Suppressing Geminivirus Infection in Nicotiana Benthamiana
Next Article in Special Issue
The Bcl-2 Family in Host-Virus Interactions
Previous Article in Journal
Epigenetic Alterations in Human Papillomavirus-Associated Cancers
Previous Article in Special Issue
Regulation of Apoptosis during Flavivirus Infection
Review

Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus

1
Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg 20251, Germany
2
Immunology and Virology Program, Centre for Ophthalmology and Visual Science, the University of Western Australia, Crawley 6009, WA, Australia
3
Centre for Experimental Immunology, Lions Eye Institute, Nedlands 6009, WA, Australia
*
Authors to whom correspondence should be addressed.
Academic Editor: Marc Kvansakul
Viruses 2017, 9(9), 249; https://doi.org/10.3390/v9090249
Received: 26 July 2017 / Revised: 27 August 2017 / Accepted: 28 August 2017 / Published: 2 September 2017
(This article belongs to the Special Issue Viral Infection and Apoptosis)
Multicellular organisms have evolved multiple genetically programmed cell death pathways that are essential for homeostasis. The finding that many viruses encode cell death inhibitors suggested that cellular suicide also functions as a first line of defence against invading pathogens. This theory was confirmed by studying viral mutants that lack certain cell death inhibitors. Cytomegaloviruses, a family of species-specific viruses, have proved particularly useful in this respect. Cytomegaloviruses are known to encode multiple death inhibitors that are required for efficient viral replication. Here, we outline the mechanisms used by the host cell to detect cytomegalovirus infection and discuss the methods employed by the cytomegalovirus family to prevent death of the host cell. In addition to enhancing our understanding of cytomegalovirus pathogenesis we detail how this research has provided significant insights into the cross-talk that exists between the various cell death pathways. View Full-Text
Keywords: apoptosis; necrosis; necroptosis; HCMV; MCMV; vMIA; vICA; vIRA; vIBO apoptosis; necrosis; necroptosis; HCMV; MCMV; vMIA; vICA; vIRA; vIBO
Show Figures

Figure 1

MDPI and ACS Style

Brune, W.; Andoniou, C.E. Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus. Viruses 2017, 9, 249. https://doi.org/10.3390/v9090249

AMA Style

Brune W, Andoniou CE. Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus. Viruses. 2017; 9(9):249. https://doi.org/10.3390/v9090249

Chicago/Turabian Style

Brune, Wolfram; Andoniou, Christopher E. 2017. "Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus" Viruses 9, no. 9: 249. https://doi.org/10.3390/v9090249

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop