Next Article in Journal
Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus
Next Article in Special Issue
Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy
Previous Article in Journal / Special Issue
The Mouse Papillomavirus Infection Model
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Viruses 2017, 9(9), 248;

Epigenetic Alterations in Human Papillomavirus-Associated Cancers

Division of Infectious Disease, Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Author to whom correspondence should be addressed.
Academic Editors: Alison A. McBride and Karl Munger
Received: 14 August 2017 / Revised: 25 August 2017 / Accepted: 25 August 2017 / Published: 1 September 2017
(This article belongs to the Special Issue Expert Views on HPV Infection)
PDF [719 KB, uploaded 4 September 2017]


Approximately 15–20% of human cancers are caused by viruses, including human papillomaviruses (HPVs). Viruses are obligatory intracellular parasites and encode proteins that reprogram the regulatory networks governing host cellular signaling pathways that control recognition by the immune system, proliferation, differentiation, genomic integrity, and cell death. Given that key proteins in these regulatory networks are also subject to mutation in non-virally associated diseases and cancers, the study of oncogenic viruses has also been instrumental to the discovery and analysis of many fundamental cellular processes, including messenger RNA (mRNA) splicing, transcriptional enhancers, oncogenes and tumor suppressors, signal transduction, immune regulation, and cell cycle control. More recently, tumor viruses, in particular HPV, have proven themselves invaluable in the study of the cancer epigenome. Epigenetic silencing or de-silencing of genes can have cellular consequences that are akin to genetic mutations, i.e., the loss and gain of expression of genes that are not usually expressed in a certain cell type and/or genes that have tumor suppressive or oncogenic activities, respectively. Unlike genetic mutations, the reversible nature of epigenetic modifications affords an opportunity of epigenetic therapy for cancer. This review summarizes the current knowledge on epigenetic regulation in HPV-infected cells with a focus on those elements with relevance to carcinogenesis. View Full-Text
Keywords: Human papillomavirus; HPV; cervical cancer; epigenetics; histone Human papillomavirus; HPV; cervical cancer; epigenetics; histone

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Soto, D.; Song, C.; McLaughlin-Drubin, M.E. Epigenetic Alterations in Human Papillomavirus-Associated Cancers. Viruses 2017, 9, 248.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top