The Mouse Papillomavirus Infection Model
Abstract
:1. Introduction
2. Mouse Papillomavirus Exhibits both Cutaneous and Mucosal Tropism
3. Certain Strains of Immunocompetent Mice Are Susceptible to MmuPV1 Infection
4. MmuPV1 Has Malignant Potential
4.1. Mouse Papillomavirus Oncogenes E6 and E7 Are Tumorigenic
4.2. Cutaneous Lesions Can Develop into Cancers
4.3. Mucosal Lesions Can Develop into Cancers
5. Immune Responses to MmuPV1 Infections
5.1. T- and B-Cell Mediated Immunity in the Control of MmuPV1 Infections
5.2. Innate Immunity in the Control of MmuPV1 Infection at Mucosal Sites
5.2.1. Neutrophils and NK Cells Are Associated with Decreased Local MmuPV1 Mucosal Infection in Immunocompetent Heterozygous (Foxn1nu/+) NU/J Mice
5.2.2. RNA Sequencing Data Support the Involvement of NK Cells and Neutrophils as Well as Type I IFNs in MmuPV1-Infected Tissues
6. Other Host-Restricted Factors in Local MmuPV1 Infections
7. Conclusions and Future Directions
Acknowledgments
Conflicts of Interest
References
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Transcripts | MmuPV1 Infected Tissues | ||
---|---|---|---|
Muzzle | Tongue | Vagina | |
IL15 | Down | Down | N.S. |
Il1rn | UP | UP | N.S. |
Il4ra | N.S. | UP | UP |
IFNar1 | N.S. | UP | N.S. |
Ifi27l2b | N.S. | Down | Down |
Ifi27 | Down | N.S. | N.S. |
Ifit2 | N.S. | N.S. | Down |
TLR5 | N.S. | UP | N.S. |
CXCR2 | UP | N.S. | N.S. |
CD53 | Down | Down | Down |
Stat3 | UP | UP | N.S. |
Stat6 | UP | UP | N.S. |
Trim23 | Down | Down | N.S. |
Trim29 | UP | N.S. | UP |
Defb4 | Down | Down | N.S. |
Defb6 | Down | Down | N.S. |
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Hu, J.; Cladel, N.M.; Budgeon, L.R.; Balogh, K.K.; Christensen, N.D. The Mouse Papillomavirus Infection Model. Viruses 2017, 9, 246. https://doi.org/10.3390/v9090246
Hu J, Cladel NM, Budgeon LR, Balogh KK, Christensen ND. The Mouse Papillomavirus Infection Model. Viruses. 2017; 9(9):246. https://doi.org/10.3390/v9090246
Chicago/Turabian StyleHu, Jiafen, Nancy M. Cladel, Lynn R. Budgeon, Karla K. Balogh, and Neil D. Christensen. 2017. "The Mouse Papillomavirus Infection Model" Viruses 9, no. 9: 246. https://doi.org/10.3390/v9090246