Next Article in Journal
Host Cell Restriction Factors that Limit Influenza A Infection
Next Article in Special Issue
Protection of Mice from Lethal Vaccinia Virus Infection by Vaccinia Virus Protein Subunits with a CpG Adjuvant
Previous Article in Journal
High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitopes on Human Papillomavirus 16
Previous Article in Special Issue
Dynamics of Pathological and Virological Findings During Experimental Calpox Virus Infection of Common Marmosets (Callithrix jacchus)
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessCase Report
Viruses 2017, 9(12), 375;

Two Distinct Clinical Courses of Human Cowpox, Germany, 2015

Institute of Medical Microbiology and Epidemiology of Infectious Diseases, University Hospital, 04103 Leipzig, Germany
Central Diagnostic Laboratory Division, Bundeswehr Institute of Microbiology, 80937 Munich, Germany
Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, 04103 Leipzig, Germany
Ear, Nose and Throat Clinic, University Hospital, 04103 Leipzig, Germany
Department of Viruses and Intracellular Agents, Bundeswehr Institute of Microbiology, 80937 Munich, Germany
Author to whom correspondence should be addressed.
Received: 23 November 2017 / Revised: 4 December 2017 / Accepted: 6 December 2017 / Published: 7 December 2017
(This article belongs to the Special Issue Smallpox and Emerging Zoonotic Orthopoxviruses: What Is Coming Next?)
Full-Text   |   PDF [2534 KB, uploaded 7 December 2017]   |  


Here we present two cases of human infection with cowpox virus with distinct clinical courses. A series of clinical photographs documents lesion progression over time. In the first case—an unvaccinated young veterinary assistant—a pustule was treated locally with cortisone. The lesion turned into a large ulcer accompanied by severe lymphadenitis. Based on her close contact to a sick stray cat, infection with cowpox virus was assumed and confirmed by virus isolation, PCR, and serology. The clinical course took up to eleven months until healing of the wound was complete. Transmission of cowpox virus from the cat was likely because a skin swab was PCR-positive and the cat had a high titer of anti-orthopoxvirus antibodies. In contrast, a rather mild clinical course of cowpox was confirmed in a 49-year-old male farmer vaccinated against smallpox. Only a small eschar developed, and wound closure was complete after 6 weeks. View Full-Text
Keywords: cowpox virus; Orthopoxvirus; skin lesion; zoonotic transmission cowpox virus; Orthopoxvirus; skin lesion; zoonotic transmission

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Eder, I.; Vollmar, P.; Pfeffer, M.; Naether, P.; Rodloff, A.C.; Meyer, H. Two Distinct Clinical Courses of Human Cowpox, Germany, 2015. Viruses 2017, 9, 375.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top