Next Article in Journal
Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated Strain
Next Article in Special Issue
Equine Immunoglobulin and Equine Neutralizing F(ab′)2 Protect Mice from West Nile Virus Infection
Previous Article in Journal
Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses
Previous Article in Special Issue
Epitope Identification and Application for Diagnosis of Duck Tembusu Virus Infections in Ducks
Open AccessArticle

Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models

1
Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
2
Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
3
D’Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, Brazil
4
Department of Immunology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
5
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA
6
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA
7
Istituto Superiore di Sanità, Deptartment of Infectious Diseases, 299 Viale Regina Elena, 00161 Rome, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Michael R. Holbrook
Viruses 2016, 8(12), 322; https://doi.org/10.3390/v8120322
Received: 16 October 2016 / Revised: 16 November 2016 / Accepted: 18 November 2016 / Published: 29 November 2016
(This article belongs to the Special Issue Advances in Flavivirus Research)
Zika virus (ZIKV) infection in utero might lead to microcephaly and other congenital defects. Since no specific therapy is available thus far, there is an urgent need for the discovery of agents capable of inhibiting its viral replication and deleterious effects. Chloroquine is widely used as an antimalarial drug, anti-inflammatory agent, and it also shows antiviral activity against several viruses. Here we show that chloroquine exhibits antiviral activity against ZIKV in Vero cells, human brain microvascular endothelial cells, human neural stem cells, and mouse neurospheres. We demonstrate that chloroquine reduces the number of ZIKV-infected cells in vitro, and inhibits virus production and cell death promoted by ZIKV infection without cytotoxic effects. In addition, chloroquine treatment partially reveres morphological changes induced by ZIKV infection in mouse neurospheres. View Full-Text
Keywords: Zika virus; chloroquine; antiviral; microcephaly; neural stem cell Zika virus; chloroquine; antiviral; microcephaly; neural stem cell
Show Figures

Figure 1

MDPI and ACS Style

Delvecchio, R.; Higa, L.M.; Pezzuto, P.; Valadão, A.L.; Garcez, P.P.; Monteiro, F.L.; Loiola, E.C.; Dias, A.A.; Silva, F.J.M.; Aliota, M.T.; Caine, E.A.; Osorio, J.E.; Bellio, M.; O’Connor, D.H.; Rehen, S.; De Aguiar, R.S.; Savarino, A.; Campanati, L.; Tanuri, A. Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models. Viruses 2016, 8, 322.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop