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Open AccessArticle

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

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State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
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Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA
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Key Lab of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China
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Authors to whom correspondence should be addressed.
Academic Editor: Curt Hagedorn
Viruses 2016, 8(1), 6; https://doi.org/10.3390/v8010006
Received: 10 October 2015 / Revised: 25 November 2015 / Accepted: 30 November 2015 / Published: 25 December 2015
(This article belongs to the Section Antivirals & Vaccines)
Influenza A viruses (IAVs) cause seasonal pandemics and epidemics with high morbidity and mortality, which calls for effective anti-IAV agents. The glycoprotein hemagglutinin of influenza virus plays a crucial role in the initial stage of virus infection, making it a potential target for anti-influenza therapeutics development. Here we found that quercetin inhibited influenza infection with a wide spectrum of strains, including A/Puerto Rico/8/34 (H1N1), A/FM-1/47/1 (H1N1), and A/Aichi/2/68 (H3N2) with half maximal inhibitory concentration (IC50) of 7.756 ± 1.097, 6.225 ± 0.467, and 2.738 ± 1.931 μg/mL, respectively. Mechanism studies identified that quercetin showed interaction with the HA2 subunit. Moreover, quercetin could inhibit the entry of the H5N1 virus using the pseudovirus-based drug screening system. This study indicates that quercetin showing inhibitory activity in the early stage of influenza infection provides a future therapeutic option to develop effective, safe and affordable natural products for the treatment and prophylaxis of IAV infections. View Full-Text
Keywords: entry inhibitor; hemagglutinin; influenza A virus; quercetin entry inhibitor; hemagglutinin; influenza A virus; quercetin
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MDPI and ACS Style

Wu, W.; Li, R.; Li, X.; He, J.; Jiang, S.; Liu, S.; Yang, J. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses 2016, 8, 6.

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