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From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis

1
Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France
2
SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France
3
Master BioSciences, Département de Biologie, ENS Lyon, 69366 Lyon Cedex 7, France
4
AIMM Therapeutics, Meibergdreef 59, 1105 BA Amsterdam Zuidoost, The Netherlands
5
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 BA Amsterdam Zuidoost, The Netherlands
6
Etablissement français du sang, 69007 Lyon, France
*
Author to whom correspondence should be addressed.
Academic Editor: Louis M. Mansky
Viruses 2015, 7(12), 6371-6386; https://doi.org/10.3390/v7122944
Received: 30 September 2015 / Revised: 16 November 2015 / Accepted: 30 November 2015 / Published: 7 December 2015
(This article belongs to the Special Issue Recent Advances in HTLV Research 2015)
The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease. This review will focus on the recent advances in the generation of immunodeficient and human hemato-lymphoid system mice with a particular emphasis on the development of mouse models for HTLV-1-mediated pathogenesis, their present limitations and the challenges yet to be addressed. View Full-Text
Keywords: adult T cell leukemia/lymphoma; HTLV-1; humanized mouse models; oncogenesis adult T cell leukemia/lymphoma; HTLV-1; humanized mouse models; oncogenesis
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MDPI and ACS Style

Pérès, E.; Bagdassarian, E.; This, S.; Villaudy, J.; Rigal, D.; Gazzolo, L.; Duc Dodon, M. From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis. Viruses 2015, 7, 6371-6386.

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