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Viruses 2012, 4(11), 3162-3178;

Interaction of Bacteriophage l with Its E. coli Receptor, LamB

Department of Biochemistry and Molecular Pharmacology, NYU Medical School, 550 First Avenue, New York, NY 10016, USA
Author to whom correspondence should be addressed.
Received: 5 October 2012 / Revised: 17 October 2012 / Accepted: 27 October 2012 / Published: 15 November 2012
(This article belongs to the Special Issue Recent Progress in Bacteriophage Research)
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The initial step of viral infection is the binding of a virus onto the host cell surface. This first viral-host interaction would determine subsequent infection steps and the fate of the entire infection process. A basic understating of the underlining mechanism of initial virus-host binding is a prerequisite for establishing the nature of viral infection. Bacteriophage λ and its host Escherichia coli serve as an excellent paradigm for this purpose. λ phages bind to specific receptors, LamB, on the host cell surface during the infection process. The interaction of bacteriophage λ with the LamB receptor has been the topic of many studies, resulting in wealth of information on the structure, biochemical properties and molecular biology of this system. Recently, imaging studies using fluorescently labeled phages and its receptor unveil the role of spatiotemporal dynamics and divulge the importance of stochasticity from hidden variables in the infection outcomes. The scope of this article is to review the present state of research on the interaction of bacteriophage λ and its E. coli receptor, LamB. View Full-Text
Keywords: bacteriophage; lambda phage; LamB receptor; protein J; single-virus tracking bacteriophage; lambda phage; LamB receptor; protein J; single-virus tracking

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Chatterjee, S.; Rothenberg, E. Interaction of Bacteriophage l with Its E. coli Receptor, LamB. Viruses 2012, 4, 3162-3178.

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