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Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1

Institute of Poultry Diseases, Free Berlin University, Königsweg 63, 14163 Berlin, Germany
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Present address: Molecular Pathogenesis and Ecology of Influenza Viruses Laboratory, Institute of Molecular Biology, Federal Research Institute for Animal Health, Friedrich Loeffler Institute, Isles of Riems, Suedufer 10, 17493 Greifswald, Germany
Viruses 2012, 4(11), 3179-3208; https://doi.org/10.3390/v4113179
Received: 23 September 2012 / Revised: 4 November 2012 / Accepted: 8 November 2012 / Published: 19 November 2012
(This article belongs to the Special Issue H5N1 Influenza Virus)
Highly pathogenic avian influenza virus (HPAIV) of subtype H5N1 causes a devastating disease in poultry but when it accidentally infects humans it can cause death. Therefore, decrease the incidence of H5N1 in humans needs to focus on prevention and control of poultry infections. Conventional control strategies in poultry based on surveillance, stamping out, movement restriction and enforcement of biosecurity measures did not prevent the virus spreading, particularly in developing countries. Several challenges limit efficiency of the vaccines to prevent outbreaks of HPAIV H5N1 in endemic countries. Alternative and complementary approaches to reduce the current burden of H5N1 epidemics in poultry should be encouraged. The use of antiviral chemotherapy and natural compounds, avian-cytokines, RNA interference, genetic breeding and/or development of transgenic poultry warrant further evaluation as integrated intervention strategies for control of HPAIV H5N1 in poultry. View Full-Text
Keywords: influenza; H5N1; control influenza; H5N1; control
MDPI and ACS Style

Abdelwhab, E.M.; Hafez, H.M. Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1. Viruses 2012, 4, 3179-3208.

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