Next Article in Journal
The Role of Humoral Innate Immunity in Hepatitis C Virus Infection
Previous Article in Journal
The Human Lung Adenocarcinoma Cell Line EKVX Produces an Infectious Xenotropic Murine Leukemia Virus
Previous Article in Special Issue
How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission
Article Menu

Export Article

Open AccessReview
Viruses 2011, 3(12), 2462-2477;

The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells

Department of Microbiology and Molecular Genetics, University of Pittsburgh, 518 Bridgeside Point II, 450 Technology Drive, Pittsburgh, PA 15219, USA
Author to whom correspondence should be addressed.
Received: 17 November 2011 / Revised: 7 December 2011 / Accepted: 15 December 2011 / Published: 21 December 2011
(This article belongs to the Special Issue Cytoskeleton in Viral Infections)
Full-Text   |   PDF [845 KB, uploaded 12 May 2015]   |  


Many diverse viruses target a polarized epithelial monolayer during host invasion. The polarized epithelium is adept at restricting the movement of solutes, ions, macromolecules, and pathogens across the mucosa. This regulation can be attributed to the presence of a junctional complex between adjacent cells and to an intricate network of actin filaments that provides support to the subapical membrane and stabilizes intercellular junctions. It is therefore not surprising that many viruses have evolved highly varied strategies to dissolve or modulate the cortical actin meshwork to promote infection of polarized cells. In this review, we will discuss the cell biological properties of the actin cytoskeleton in polarized epithelial cells and review the known mechanisms utilized by viral pathogens to manipulate this system in order to facilitate their infection. View Full-Text
Keywords: polarized epithelium; actin cytoskeleton; tight junctions; virus entry polarized epithelium; actin cytoskeleton; tight junctions; virus entry

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Delorme-Axford, E.; Coyne, C.B. The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells. Viruses 2011, 3, 2462-2477.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top