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HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear

Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94158-2280, USA
Author to whom correspondence should be addressed.
Viruses 2010, 2(10), 2226-2234;
Received: 2 September 2010 / Revised: 1 October 2010 / Accepted: 1 October 2010 / Published: 6 October 2010
(This article belongs to the Section Editorial)
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HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat:P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747-751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.
Keywords: HIV-1; Tat; transcription; P-TEFb; retroviruses HIV-1; Tat; transcription; P-TEFb; retroviruses

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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D’Orso, I.; Frankel, A.D. HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear. Viruses 2010, 2, 2226-2234.

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