Next Article in Journal
Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika Virus
Previous Article in Journal
Prevalence and Risk Factors of Occult HCV Infection in the Adult Population of Mexico City
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Viruses
Volume 17
Issue 2
10.3390/v17020237
viruses-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Vaccinia Virus Vector Bivalent Norovirus Vaccine

by
Yunbo Bai
1,2,†,
Xi Wu
2,†,
Yanru Shen
2,
Liangliang Wang
2,
Ziqi Cheng
2,
Yeqing Sun
2,
Hao Wu
2,
Qingfeng Zhang
2,
Ziqi Sun
1,2,
Chenchen He
1,2,
Binfan Liao
2,
Weijin Huang
2,* and
Huanzhang Xia
1,*
1
School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
2
State Key Laboratory of Drug Regulatory Science, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Division of HIV/AIDS and Sexually Transmitted Virus Vaccines, Beijing 102629, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Viruses 2025, 17(2), 237; https://doi.org/10.3390/v17020237
Submission received: 24 December 2024 / Revised: 31 January 2025 / Accepted: 1 February 2025 / Published: 9 February 2025
(This article belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Browse Figures
Versions Notes

Abstract

Norovirus is a major etiological agent of nonbacterial gastroenteritis around the world. Due to its in vitro culture complexity, high genome diversity, and the lack of cross-reactive immunity between genogroups, there is an unmet urgent need for polyvalent norovirus vaccines that provide broad-spectrum protection, and no vaccine has gained global approval to date. In this study, we constructed a bivalent norovirus vaccine, based on the highly attenuated poxvirus [strain VG9] vector, expressing the major capsid protein VP1 from genotypes GII.4 and GII.17. VG9-NOR exhibited a comparable replication ability to the authentic virus while preserving good safety. After the intramuscular and intranasal immunization of mice, VG9-NOR induced high IgG- and IgA-binding antibody (Ab) titers against GII.4 and GII.17, increased the secretion of GII.4 and GII.17-specific HGBA-blocking antibodies, and enhanced GII.17-specific mucosal immunity. Furthermore, VG9-NOR also induced a Th1-mediated cellular response. These results demonstrate that the polyvalent poxvirus vector vaccine expressing VP1 variants from different subtypes is able to elicit effective protection. Our study highlights the VG9 vector as a highly promising candidate for the development of polyvalent norovirus vaccines.
Keywords: norovirus; poxvirus vector; bivalent vaccine; immune response norovirus; poxvirus vector; bivalent vaccine; immune response

Share and Cite

MDPI and ACS Style

Bai, Y.; Wu, X.; Shen, Y.; Wang, L.; Cheng, Z.; Sun, Y.; Wu, H.; Zhang, Q.; Sun, Z.; He, C.; et al. Vaccinia Virus Vector Bivalent Norovirus Vaccine. Viruses 2025, 17, 237. https://doi.org/10.3390/v17020237

AMA Style

Bai Y, Wu X, Shen Y, Wang L, Cheng Z, Sun Y, Wu H, Zhang Q, Sun Z, He C, et al. Vaccinia Virus Vector Bivalent Norovirus Vaccine. Viruses. 2025; 17(2):237. https://doi.org/10.3390/v17020237

Chicago/Turabian Style

Bai, Yunbo, Xi Wu, Yanru Shen, Liangliang Wang, Ziqi Cheng, Yeqing Sun, Hao Wu, Qingfeng Zhang, Ziqi Sun, Chenchen He, and et al. 2025. "Vaccinia Virus Vector Bivalent Norovirus Vaccine" Viruses 17, no. 2: 237. https://doi.org/10.3390/v17020237

APA Style

Bai, Y., Wu, X., Shen, Y., Wang, L., Cheng, Z., Sun, Y., Wu, H., Zhang, Q., Sun, Z., He, C., Liao, B., Huang, W., & Xia, H. (2025). Vaccinia Virus Vector Bivalent Norovirus Vaccine. Viruses, 17(2), 237. https://doi.org/10.3390/v17020237

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop