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Volume 15
Issue 3
10.3390/v15030793
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Communication

Correlation of SARS-CoV-2 Neutralization with Antibody Levels in Vaccinated Individuals

by
Shazeda Haque Chowdhury
1,
Sean Riley
1,
Riley Mikolajczyk
1,
Lauren Smith
1,
Lakshmanan Suresh
2,3 and
Amy Jacobs
1,*
1
Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14213, USA
2
Department of Oral Diagnostic Sciences, State University of New York at Buffalo, Buffalo, NY 14215, USA
3
KSL Diagnostics, Inc., Buffalo, NY 14225, USA
*
Author to whom correspondence should be addressed.
Viruses 2023, 15(3), 793; https://doi.org/10.3390/v15030793
Submission received: 10 March 2023 / Revised: 19 March 2023 / Accepted: 20 March 2023 / Published: 21 March 2023
(This article belongs to the Special Issue RNA Viruses and Antibody Response)
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Abstract

Neutralizing antibody titers are an important measurement of the effectiveness of vaccination against SARS-CoV-2. Our laboratory has set out to further verify the functionality of these antibodies by measuring the neutralization capacity of patient samples against infectious SARS-CoV-2. Samples from patients from Western New York who had been vaccinated with the original Moderna and Pfizer vaccines (two doses) were tested for neutralization of both Delta (B.1.617.2) and Omicron (BA.5). Strong correlations between antibody levels and neutralization of the delta variant were attained; however, antibodies from the first two doses of the vaccines did not have good neutralization coverage of the subvariant omicron BA.5. Further studies are ongoing with local patient samples to determine correlation following updated booster administration.
Keywords: SARS-CoV-2; COVID-19; antibody response; RNA viruses SARS-CoV-2; COVID-19; antibody response; RNA viruses

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MDPI and ACS Style

Chowdhury, S.H.; Riley, S.; Mikolajczyk, R.; Smith, L.; Suresh, L.; Jacobs, A. Correlation of SARS-CoV-2 Neutralization with Antibody Levels in Vaccinated Individuals. Viruses 2023, 15, 793. https://doi.org/10.3390/v15030793

AMA Style

Chowdhury SH, Riley S, Mikolajczyk R, Smith L, Suresh L, Jacobs A. Correlation of SARS-CoV-2 Neutralization with Antibody Levels in Vaccinated Individuals. Viruses. 2023; 15(3):793. https://doi.org/10.3390/v15030793

Chicago/Turabian Style

Chowdhury, Shazeda Haque, Sean Riley, Riley Mikolajczyk, Lauren Smith, Lakshmanan Suresh, and Amy Jacobs. 2023. "Correlation of SARS-CoV-2 Neutralization with Antibody Levels in Vaccinated Individuals" Viruses 15, no. 3: 793. https://doi.org/10.3390/v15030793

APA Style

Chowdhury, S. H., Riley, S., Mikolajczyk, R., Smith, L., Suresh, L., & Jacobs, A. (2023). Correlation of SARS-CoV-2 Neutralization with Antibody Levels in Vaccinated Individuals. Viruses, 15(3), 793. https://doi.org/10.3390/v15030793

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