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Article

Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice

1
Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel
2
Department of Biological Regulation, Weizmann Institute of Science, Herzel 234, Rehovot P.O. Box 26, Israel
3
Department of Biomolecular Sciences, Weizmann Institute of Science, Herzel 234, Rehovot P.O. Box 26, Israel
*
Authors to whom correspondence should be addressed.
Academic Editors: Elmostafa Bahraoui and Juan C. De la Torre
Viruses 2022, 14(8), 1627; https://doi.org/10.3390/v14081627
Received: 26 April 2022 / Revised: 1 July 2022 / Accepted: 19 July 2022 / Published: 26 July 2022
(This article belongs to the Section SARS-CoV-2 and COVID-19)
The COVID-19 pandemic caused by the SARS-CoV-2 infection induced lung inflammation characterized by cytokine storm and fulminant immune response of both resident and migrated immune cells, accelerating alveolar damage. In this work we identified members of the matrix metalloprotease (MMPs) family associated with lung extra-cellular matrix (ECM) destruction using K18-hACE2-transgenic mice (K18-hACE2) infected intranasally with SARS-CoV-2. Five days post infection, the lungs exhibited overall alveolar damage of epithelial cells and massive leukocytes infiltration. A substantial pulmonary increase in MMP8, MMP9, and MMP14 in the lungs post SARS-CoV-2 infection was associated with degradation of ECM components including collagen, laminin, and proteoglycans. The process of tissue damage and ECM degradation during SARS-CoV-2 lung infection is suggested to be associated with activity of members of the MMPs family, which in turn may be used as a therapeutic intervention. View Full-Text
Keywords: COVID-19; extra-cellular matrix (ECM); K18-hACE2; matrix-metalloproteases (MMP); SARS-CoV-2 COVID-19; extra-cellular matrix (ECM); K18-hACE2; matrix-metalloproteases (MMP); SARS-CoV-2
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MDPI and ACS Style

Gutman, H.; Aftalion, M.; Melamed, S.; Politi, B.; Nevo, R.; Havusha-Laufer, S.; Achdout, H.; Gur, D.; Israely, T.; Dachir, S.; Mamroud, E.; Sagi, I.; Vagima, Y. Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice. Viruses 2022, 14, 1627. https://doi.org/10.3390/v14081627

AMA Style

Gutman H, Aftalion M, Melamed S, Politi B, Nevo R, Havusha-Laufer S, Achdout H, Gur D, Israely T, Dachir S, Mamroud E, Sagi I, Vagima Y. Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice. Viruses. 2022; 14(8):1627. https://doi.org/10.3390/v14081627

Chicago/Turabian Style

Gutman, Hila, Moshe Aftalion, Sharon Melamed, Boaz Politi, Reinat Nevo, Sapir Havusha-Laufer, Hagit Achdout, David Gur, Tomer Israely, Shlomit Dachir, Emanuelle Mamroud, Irit Sagi, and Yaron Vagima. 2022. "Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice" Viruses 14, no. 8: 1627. https://doi.org/10.3390/v14081627

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