Acquired Hip Dysplasia in Children with Congenital Zika Virus Infection in the First Four Years of Life
Abstract
:1. Introduction
2. Materials and Methods
2.1. Inclusion and Exclusion Criteria
2.2. Study Procedures
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Dick, G.W.A.; Kitchen, S.F.; Haddow, A.J. Zika virus. I. Isolations and serological specificity. Trans. R. Soc. Trop. Med. Hyg. 1952, 46, 509–520. [Google Scholar] [CrossRef]
- Zanluca, C.; de Melo, V.C.A.; Mosimann, A.L.P.; Santos, G.I.V.D.; Santos, C.N.D.D.; Luz, K. FirstreportofautochthonoustransmissionofZikavirusinBrazil. Mem. Inst. Oswaldo Cruz. 2015, 110, 569–572. [Google Scholar] [CrossRef] [PubMed]
- Campos, G.S.; Bandeira, A.C.; Sardi, S.I. ZikaVirusOutbreak,Bahia,Brazil. Emerg. Infect. Dis. 2015, 21, 1885–1886. [Google Scholar] [CrossRef] [PubMed]
- de Oliveira, W.K.; Cortez-Escalante, J.; De Oliveira, W.T.G.H.; Carmo, G.M.I.D.; Henriques, C.M.P.; Coelho, G.E.; de França, G.V. A. Increasein Reported Prevalenceof Microcephaly in Infants Bornto WomenLivingin Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy—Brazil, 2015. MMWR Morb. Mortal Wkly. Rep. 2016, 65, 242–247. [Google Scholar]
- Cauchemez, S.; Besnard, M.; Bompard, P.; Dub, T.; Guillemette-Artur, P.; Eyrolle-Guignot, D.; Salje, H.; Van Kerkhove, M.D.; Abadie, V.; Garel, C.; et al. .AssociationbetweenZikavirusandmicrocephalyinFrenchPolynesia, 2013–2015: A retrospective study. Lancet Lond. Engl. 2016, 387, 2125–2132. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Schuler-Faccini, L.; Ribeiro, E.M.; Feitosa, I.M.; Horovitz, D.D.; Cavalcanti, D.P.; Pessoa, A.; Doriqui, M.J.R.; Neri, J.I.; de Pina Neto, J.M.; Wanderley, H.Y.; et al. .PossibleAssociationBetweenZikaVirusInfectionandMicrocephaly—Brazil,2015. MMWR Morb. Mortal Wkly. Rep. 2016, 65, 59–62. [Google Scholar] [CrossRef]
- Moore, C.A.; Staples, J.E.; Dobyns, W.B.; Pessoa, A.; Ventura, C.V.; DaFonseca, E.B.; Ribeiro, E.M.; Ventura, L.O.; Neto, N.N.; Arena, J.F.; et al. Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians. JAMA Pediatr. 2017, 171, 288–295. [Google Scholar] [CrossRef] [Green Version]
- Ferreira, H.N.C.; Schiariti, V.; Regalado, I.C.R.; Sousa, K.G.; Pereira, S.A.; Fechine, C.P.N.D.S.; Longo, E. Functioning and Disability Profile of Children with Microcephaly Associated with Congenital Zika Virus Infection. Int. J. Environ. Res. Public Health 2018, 15, 1107. [Google Scholar] [CrossRef] [Green Version]
- Marques, F.J.P.; Teixeira, M.C.S.; Barra, R.R.; de Lima, F.M.; Dias, B.L.S.; Pupe, C.; Nascimento, O.J.M.; Leyser, M. Children Born With Congenital Zika Syndrome Display Atypical Gross Motor Development and a Higher Risk for Cerebral Palsy. J. Child Neurol. 2018, 34, 81–85. [Google Scholar] [CrossRef]
- Guille, J.T.; Pizzutillo, P.D.; MacEwen, G.D. Development dysplasia of the hip from birth to six months. J. Am. Acad. Orthop. Surg. 2000, 8, 232–242. [Google Scholar] [CrossRef] [Green Version]
- Guarniero, R. Dysplasia of Hip Development: Update. Rev. Bras. de Ortop. (English Ed.) 2010, 45, 116–121. [Google Scholar] [CrossRef]
- Huser, A.; Mo, M.; Hosseinzadeh, P. Hip Surveillance in Children with Cerebral Palsy. Orthop. Clin. N. Am. 2018, 49, 181–190. [Google Scholar] [CrossRef] [PubMed]
- Wynter, M.; Gibson, N.; Kentish, M.; Love, S.; Thomason, P.; Graham, H.K. The consensus statement on Hip Surveillance for Children with Cerebral Palsy: Australian Standards of Care. J. Pediatr. Rehabilitation Med. 2011, 4, 183–195. [Google Scholar] [CrossRef] [PubMed]
- Miller, S.D.; Mayson, T.A.; Mulpuri, K.; O’Donnell, M.E. Developing a province-wide hip surveillance program for children with cerebral palsy: From evidence to consensus to program implementation: A mini-review. J. Pediatr. Orthop. B 2019, 29, 517–522. [Google Scholar] [CrossRef] [PubMed]
- Wynter, M.; Gibson, N.; Willoughby, K.L.; Love, S.; Kentish, M.; Thomason, P.; Graham, H.K.; the National Hip Surveillance Working Group. Australian hip surveillance guidelines for children with cerebral palsy:5-yearreview. Dev.Med.ChildNeurol. 2015, 57, 808–820. [Google Scholar] [CrossRef]
- Miller, S.; Mulpuri, K.; O’Donnell, M. Hip Surveillance Program for Children with CerebralPalsy. In British Columbia’s Consensus on Hip Surveillance for Children with Cerebral Palsy; Child Health: Vancouver, BC, Canada, 2018; Volume 16. [Google Scholar]
- Lanciotti, R.S.; Kosoy, O.L.; Laven, J.J.; Velez, J.O.; Lambert, A.J.; Johnson, A.J.; Stanfield, S.M.; Duffy, M.R. Geneticand Serologic Propertiesof Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007. Emerg. Infect. Dis. 2008, 14, 1232–1239. [Google Scholar] [CrossRef]
- Villar, J.; Ismail, L.C.; Victora, C.G.; Ohuma, E.O.; Bertino, E.; Altman, D.G.; Lambert, A.; Papageorghiou, A.T.; Carvalho, M.; Jaffer, Y.A.; et al. International standards for newborn weight, length, and head circumference by gestational age and sex: The Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet 2014, 384, 857–868. [Google Scholar] [CrossRef]
- Ribeiro, C.T.M.; Hamanaka, T.; Pone, S.; Aibe, M.S.; Gomes, S.C.; Nielsen-Saines, K.; Brickley, E.B.; Moreira, M.E.; Pone, M. Gross motor function in children with Congenital Zika Syndrome from Rio de Janeiro, Brazil. Eur. J. Pediatr. 2021, 181, 783–788. [Google Scholar] [CrossRef]
- Palisano, R.; Rosenbaum, P.; Walter, S.; Russell, D.; Wood, E.; Galuppi, B. Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev. Med. Child Neurol. 2008, 39, 214–223. [Google Scholar] [CrossRef]
- Palisano, R.J.; Rosenbaum, P.; Bartlett, D.; Livingston, M.H. Content validity of the expanded and revised Gross Motor Function Classification System. Dev. Med. Child Neurol. 2008, 50, 744–750. [Google Scholar] [CrossRef]
- McDowell, B. The Gross Motor Function Classification System—Expanded and Revised. Dev. Med. Child Neurol. 2008, 50, 725. [Google Scholar] [CrossRef] [PubMed]
- Hamanaka, T.; Ribeiro, C.T.M.; Pone, S.; Gomes, S.C.; Nielsen-Saines, K.; Brickley, E.B.; Moreira, M.E.; Pone, M. Longitudinal Follow-Up of Gross Motor Function in Children with Congenital Zika Virus Syndrome from a Cohort in Rio de Janeiro, Brazil. Viruses 2022, 14, 1173. [Google Scholar] [CrossRef] [PubMed]
- Chagas, P.S.C.; Defilipo, E.C.; Lemos, R.A.; Mancini, M.C.; Frônio, J.S.; Carvalho, R.M. Classificação da função motora e do desempenho funcional de crianças com paralisia cerebral. Braz. J. Phys. Ther. 2008, 12, 409–416. [Google Scholar] [CrossRef] [Green Version]
- van der Linden, V.; Rolim Filho, E.L.; Lins, O.G.; van der Linden, A.; Aragão, M.D.; Brainer-Lima, A.M.; Cruz, D.D.; Rocha, M.A.; da Silva, P.F.; Carvalho, M.D.; et al. Congenital Zika syndrome with arthrogryposis: Retrospective case series study. BMJ 2016, 354, i3899. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Serpa, S.C.; de Melo, A.C.M.G.; Gomes Lins, O.; van der Linden, V.; Leite Rolim Filho, E.; Oliveira Dos Santos, A.C. Orthopedic findings in arthrogryposis and congenital Zika syndrome: A case series. Birth Defects Res. 2020, 112, 385–392. [Google Scholar] [CrossRef] [PubMed]
- Lebov, J.F.; Brown, L.M.; MacDonald, P.D.; Robertson, K.; Bowman, N.M.; Hooper, S.R.; Becker-Dreps, S. Review: Evidence of Neurological Sequelae in Children With Acquired Zika Virus Infection. Pediatr. Neurol. 2018, 85, 16–20. [Google Scholar] [CrossRef]
- Alves, L.V.; E Paredes, C.; Silva, G.C.; Mello, J.G.; Alves, J.G. Neurodevelopment of 24 children born in Brazil with congenital Zika syndrome in 2015: A case series study. BMJ Open 2018, 8, e021304. [Google Scholar] [CrossRef] [Green Version]
- Melo, A.; Gama, G.L.; Júnior, R.A.D.S.; De Assunção, P.L.; Tavares, J.S.; Da Silva, M.B.; Costa, K.N.F.S.; Vânia, M.L.; A Evangelista, M.; Amorim, M. Motor function in children with congenital Zika syndrome. Dev. Med. Child Neurol. 2019, 62, 221–226. [Google Scholar] [CrossRef]
- Hägglund, G.; Lauge-Pedersen, H.; Wagner, P. Characteristics of children with hip displacement in cerebral palsy. BMC Musculoskelet. Disord. 2007, 8, 101. [Google Scholar] [CrossRef] [Green Version]
- Lins, L.A.; Watkins, C.J.; Shore, B.J. Natural History of Spastic Hip Disease. J. Pediatr. Orthop. 2019, 39, S33–S37. [Google Scholar] [CrossRef]
- Penner, M.; Xie, W.Y.; Binepal, N.; Switzer, L.; Fehlings, D. Characteristics of Pain in Children and Youth With Cerebral Palsy. Pediatrics 2013, 132, e407–e413. [Google Scholar] [CrossRef] [PubMed]
- Yildiz, C.; Demirkale, I. Hip problems in cerebral palsy: Screening, diagnosis and treatment. Curr. Opin. Pediatr. 2014, 26, 85–92. [Google Scholar] [CrossRef] [PubMed]
- Miller, S.D.; Juricic, M.; Hesketh, K.; McLean, L.; Magnuson, S.; Gasior, S.; Schaeffer, E.; O'Donnell, M.; Mulpuri, K. Prevention of hip displacement in children with cerebral palsy: A systematic review. Dev. Med. Child Neurol. 2017, 59, 1130–1138. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Picciolini, O.; Consonni, D.; Cozzaglio, M.; Porro, M.; Gasparroni, V.; Panou, A.; Mosca, F.; Portinaro, N.M. Canwepreventhipdislocationinchildrenwithcerebralpalsy?Effectsofposturalmanagement. Eur. J. Phys. Rehabil. Med. 2016, 52, 682–690. [Google Scholar] [PubMed]
N (%) | |
---|---|
Sex | |
Male | 39 (61%) |
Head circumference | |
Normal | 4 (6%) |
Microcephaly | 60 (94%) |
Severe | 37 (58%) |
Moderate | 23 (36%) |
Child ZIKV RT-PCR result | |
Positive | 11 (17%) |
Negative | 19 (30%) |
Not performed | 34 (53%) |
GMFCS classification—first assessment | |
I | 0 |
II | 4 (6%) |
III | 2 (3%) |
IV | 40 (63%) |
V | 18 (28%) |
GMFCS classification—last assessment | |
I | 4 (6%) |
II | 1 (2%) |
III | 4 (6%) |
IV | 47 (73.5%) |
V | 8 (12.5%) |
Hip dysplasia | |
Yes | 26 (41%) |
Unilateral | 16 (25%) |
Right | 11 (17%) |
Left | 5 (8%) |
Bilateral | 10 (16%) |
No | 38 (59%) |
Moment of diagnosis of hipdysplasia | |
First evaluation | 18 (69%) |
Second evaluation | 5 (19%) |
Third evaluation | 2 (8%) |
Fourth evaluation | 1 (4%) |
(A) | Microcephaly | ||||
Yes (N = 60) | No (N = 4) | ||||
Moderate (N = 23) | Severe (N = 37) | ||||
Hip dysplasia | Yes | 4 (17%) | 22 (59%) | 0 | |
No | 19 (83%) | 15 (31%) | 4 (100%) | ||
(B) | GMFCS * | ||||
I to II (mild) (N = 5) | III (moderate) (N = 5) | IV and V (severe) (N = 55) | |||
Hip dysplasia | Yes | 0 | 0 | 26 (47%) | |
No | 5 (100%) | 4 (100%) | 29 (53%) |
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Pone, M.V.d.S.; Gomes da Silva, T.O.; Ribeiro, C.T.M.; Aguiar, E.B.d.; Mendes, P.H.B.; Gomes Junior, S.C.d.S.; Hamanaka, T.; Zin, A.A.; Pereira Junior, J.P.; Moreira, M.E.L.; et al. Acquired Hip Dysplasia in Children with Congenital Zika Virus Infection in the First Four Years of Life. Viruses 2022, 14, 2643. https://doi.org/10.3390/v14122643
Pone MVdS, Gomes da Silva TO, Ribeiro CTM, Aguiar EBd, Mendes PHB, Gomes Junior SCdS, Hamanaka T, Zin AA, Pereira Junior JP, Moreira MEL, et al. Acquired Hip Dysplasia in Children with Congenital Zika Virus Infection in the First Four Years of Life. Viruses. 2022; 14(12):2643. https://doi.org/10.3390/v14122643
Chicago/Turabian StylePone, Marcos Vinicius da Silva, Tallita Oliveira Gomes da Silva, Carla Trevisan Martins Ribeiro, Elisa Barroso de Aguiar, Pedro Henrique Barros Mendes, Saint Clair dos Santos Gomes Junior, Tatiana Hamanaka, Andrea Araujo Zin, José Paulo Pereira Junior, Maria Elisabeth Lopes Moreira, and et al. 2022. "Acquired Hip Dysplasia in Children with Congenital Zika Virus Infection in the First Four Years of Life" Viruses 14, no. 12: 2643. https://doi.org/10.3390/v14122643
APA StylePone, M. V. d. S., Gomes da Silva, T. O., Ribeiro, C. T. M., Aguiar, E. B. d., Mendes, P. H. B., Gomes Junior, S. C. d. S., Hamanaka, T., Zin, A. A., Pereira Junior, J. P., Moreira, M. E. L., Nielsen-Saines, K., & Pone, S. M. (2022). Acquired Hip Dysplasia in Children with Congenital Zika Virus Infection in the First Four Years of Life. Viruses, 14(12), 2643. https://doi.org/10.3390/v14122643