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Viruses
Volume 14
Issue 1
10.3390/v14010024
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Brief Report

Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique

by
Cremildo Maueia
1,2,3,*,
Alltalents Murahwa
1,
Alice Manjate
2,
Soren Andersson
4,5,
Jahit Sacarlal
2,
Darlene Kenga
2,
Tufária Mussá
2 and
Anna-Lise Williamson
1,6,7
1
Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa
2
Departamento de Microbiologia, Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo P.O. Box 257, Mozambique
3
Instituto Nacional de Saúde, Vila de Marracuene, Maputo 3943, Mozambique
4
School of Medical Sciences, Örebro University, 702 81 Örebro, Sweden
5
Unit for Vaccination Programs, Public Health Agency of Sweden, 171 65 Solna, Sweden
6
Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa
7
SAMRC Gynaecological Cancer Research Centre, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa
*
Author to whom correspondence should be addressed.
Viruses 2022, 14(1), 24; https://doi.org/10.3390/v14010024
Submission received: 21 October 2021 / Revised: 10 December 2021 / Accepted: 18 December 2021 / Published: 23 December 2021
(This article belongs to the Section Human Virology and Viral Diseases)
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Abstract

Background: Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and other anogenital cancers. An association between human immunodeficiency virus (HIV) infection and higher HPV incidence and prevalence are commonly reported. This study was conducted to demonstrate HPV prevalence, genotypes and its characteristics, according to the HIV status in women from Maputo in Mozambique. Methods: A total of 233 participants with ages ranging from fourteen to forty-five were included. Cervical samples were collected, DNA extracted, and HPV genotyping was performed using the HPV Direct Flow CHIP Kit. Results: In total, 177 HIV-negative and 56 HIV-positive women were included in the analysis. The overall HPV prevalence was 63% and was significantly higher among HIV-positive women (79% versus 58% among HIV-negative women; p = 0.005). The prevalence of multiple HPV type infections was 32%. High-risk HPV types 52, 68, 35, 18 and 16 were the most frequent. A higher proportion of HIV-positive women had multiple HPV types compared with HIV-negative women. Conclusions: This study demonstrated a high prevalence of HPV in the study cohort. HIV-positive women were identified as having the highest HPV prevalence and infection with multiple HPV types across all ages. High-risk genotypes were the most commonly found.
Keywords: human papillomavirus; human immunodeficiency virus; women human papillomavirus; human immunodeficiency virus; women

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MDPI and ACS Style

Maueia, C.; Murahwa, A.; Manjate, A.; Andersson, S.; Sacarlal, J.; Kenga, D.; Mussá, T.; Williamson, A.-L. Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique. Viruses 2022, 14, 24. https://doi.org/10.3390/v14010024

AMA Style

Maueia C, Murahwa A, Manjate A, Andersson S, Sacarlal J, Kenga D, Mussá T, Williamson A-L. Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique. Viruses. 2022; 14(1):24. https://doi.org/10.3390/v14010024

Chicago/Turabian Style

Maueia, Cremildo, Alltalents Murahwa, Alice Manjate, Soren Andersson, Jahit Sacarlal, Darlene Kenga, Tufária Mussá, and Anna-Lise Williamson. 2022. "Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique" Viruses 14, no. 1: 24. https://doi.org/10.3390/v14010024

APA Style

Maueia, C., Murahwa, A., Manjate, A., Andersson, S., Sacarlal, J., Kenga, D., Mussá, T., & Williamson, A.-L. (2022). Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique. Viruses, 14(1), 24. https://doi.org/10.3390/v14010024

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