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Article

Subclinical Infection and Transmission of Clade 2.3.4.4 H5N6 Highly Pathogenic Avian Influenza Virus in Mandarin Duck (Aix galericulata) and Domestic Pigeon (Columbia livia domestica)

1
Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea
2
Laboratory of Veterinary Microbiology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea
3
Wildlife Disease Response Team, National Institute of Wildlife Disease Control and Prevention, Gwangju 62407, Korea
4
Department of Pathobiology and Veterinary Science, The University of Connecticut, Storrs, CT 06269, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Kateri Bertran, Martí Cortey and Miria F. Criado
Viruses 2021, 13(6), 1069; https://doi.org/10.3390/v13061069
Received: 30 April 2021 / Revised: 27 May 2021 / Accepted: 1 June 2021 / Published: 4 June 2021
(This article belongs to the Special Issue Viral Shedding and Transmission in Zoonotic Diseases)
Since 2014, H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIV) have caused outbreaks in wild birds and poultry in multiple continents, including Asia, Europe, Africa, and North America. Wild birds were suspected to be the sources of the local and global spreads of HPAIV. This study evaluated the infectivity, pathogenicity, and transmissibility of clade 2.3.4.4 H5N6 HPAIV in mandarin ducks (Aixgalericulata) and domestic pigeons (Columbia livia domestica). None of the birds used in this study, 20 mandarin ducks or 8 pigeons, showed clinical signs or mortality due to H5N6 HPAI infection. Two genotypes of H5N6 HPAIV showed replication and transmission by direct and indirect contact between mandarin ducks. H5N6 HPAIV replicated and transmitted by direct contact between pigeons, although the viral shedding titer and duration were relatively lower and shorter than those in mandarin ducks. Influenza virus antigen was detected in various internal organs of infected mandarin ducks and pigeons, indicating systemic infection. Therefore, our results indicate mandarin ducks and pigeons can be subclinically infected with clade 2.3.4.4 H5N6 HPAIV and transfer the virus to adjacent birds. The role of mandarin ducks and pigeons in the spread and prevalence of clade 2.3.4.4 H5N6 viruses should be carefully monitored. View Full-Text
Keywords: highly pathogenic avian influenza; H5N6; clade 2.3.4.4; pathogenicity; wild bird; mandarin duck; pigeon highly pathogenic avian influenza; H5N6; clade 2.3.4.4; pathogenicity; wild bird; mandarin duck; pigeon
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MDPI and ACS Style

Jeong, S.; Kwon, J.-H.; Lee, S.-H.; Kim, Y.-J.; Jeong, J.-H.; Park, J.-E.; Jheong, W.-H.; Lee, D.-H.; Song, C.-S. Subclinical Infection and Transmission of Clade 2.3.4.4 H5N6 Highly Pathogenic Avian Influenza Virus in Mandarin Duck (Aix galericulata) and Domestic Pigeon (Columbia livia domestica). Viruses 2021, 13, 1069. https://doi.org/10.3390/v13061069

AMA Style

Jeong S, Kwon J-H, Lee S-H, Kim Y-J, Jeong J-H, Park J-E, Jheong W-H, Lee D-H, Song C-S. Subclinical Infection and Transmission of Clade 2.3.4.4 H5N6 Highly Pathogenic Avian Influenza Virus in Mandarin Duck (Aix galericulata) and Domestic Pigeon (Columbia livia domestica). Viruses. 2021; 13(6):1069. https://doi.org/10.3390/v13061069

Chicago/Turabian Style

Jeong, Sol, Jung-Hoon Kwon, Sun-Hak Lee, Yu-Jin Kim, Jei-Hyun Jeong, Jung-Eun Park, Weon-Hwa Jheong, Dong-Hun Lee, and Chang-Seon Song. 2021. "Subclinical Infection and Transmission of Clade 2.3.4.4 H5N6 Highly Pathogenic Avian Influenza Virus in Mandarin Duck (Aix galericulata) and Domestic Pigeon (Columbia livia domestica)" Viruses 13, no. 6: 1069. https://doi.org/10.3390/v13061069

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